Combine Cymbalta and Coumadin

Drug Interactions and Combined Side Effects of
Cymbalta

and Coumadin

Combine Cymbalta with Coumadin. To make a decision about taking Cymbalta and Coumadin, click here for a Medication Risk Map showing their individual and Combined Risks

Cymbalta and Coumadin have 120 combined Side Effects total
57 are Life Threatening
9 Occur Most Frequently

Click here for Drug Interactions and Side Effects of Cymbalta.
Click here for Drug Interactions and Side Effects of Coumadin.
Click here to compare Cymbalta vs Coumadin.

Uses of Cymbalta

Cymbalta is also known by the generic name Duloxetine

USES:
Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).

Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

Uses of Coumadin

Coumadin is also known by the generic name Warfarin

USES:
This medication is used to treat blood clots (such as in deep vein thrombosis-DVT or pulmonary embolus-PE) and/or to prevent new clots from forming in your body. Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack. Conditions that increase your risk of developing blood clots include a certain type of irregular heart rhythm (atrial fibrillation), heart valve replacement, recent heart attack, and certain surgeries (such as hip/knee replacement).

Warfarin is commonly called a "blood thinner," but the more correct term is "anticoagulant." It helps to keep blood flowing smoothly in your body by decreasing the amount of certain substances (clotting proteins) in your blood.

Cymbalta and Coumadin Combined Have 57 Life Threatening (Major) Side Effects

Critcal Seriouosness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Acute Infection of the Nose, Throat or Sinus - Upper Respiratory Infection is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Adrenal Hemorrhage is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Allergic Reaction caused by a Drug - Hypersensitivity Drug Reactions is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Behaving with Excessive Cheerfulness and Activity - Manic Disorder is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Bloody Urine - Hematuria is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Bruise - Bruising is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Burning Stomach - Gastritis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Canker Sore - Aphthous Stomatitis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Decreased White Blood Cells - Leukopenia is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Deficiency of Granulocytes a Type of White Blood Cell - Agranulocytosis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Diarrhea is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Feel Like Throwing Up - Nausea is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Feeling Faint - Fainting is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Foot Pain - Feet Pain is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Gangrene is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Having Thoughts of Suicide - Suicidal Ideation is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Hemorrhage of Blood Under the Skin - Ecchymosis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Hemorrhage is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Hepatitis caused by Drugs - Drug-Induced Hepatitis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Hepatitis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - High Blood Pressure - Hypertension is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Hives - Urticaria is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Increased Risk of Bleeding is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Inflammation of the Liver with Stoppage of Bile Flow - Cholestatic Hepatitis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Kidney Disease - Renal Disease is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Lack of Blood Supply to the Brain - Cerebral Ischemia is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Mood Changes is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Muscle Pain - Myalgia is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Needing to Urinate Immediately - Urinary Urgency is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Neuroleptic Malignant Syndrome is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Numbness and Tingling - Paresthesia is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Obstruction of Blood Vessel caused by a Fat Globule - Cholesterol Embolism is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Pain in Arms or Legs - Limb Pain is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Pancreatitis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Problem with Adrenal Gland - Acute Adrenocortical Insufficiency is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Puffy Face from Water Retention - Facial Edema is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Purplish Discoloration of the Skin that Looks Like Netting - Livedo Reticularis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Rash - Skin Rash is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Red Blood in Bowel Movement - Bloody Stools is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Redness of Skin - Erythema is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Serotonin Syndrome - Adverse Drug Interaction - Serotonin Syndrome is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Stevens-Johnson Syndrome is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Stomach Cramps - Abdominal Pain with Cramps is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Stomach Ulcer - Gastric Ulcer is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Suicidal is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Syndrome of Inappropriate Antidiuretic Hormone Secretion - SIADH Syndrome is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Throwing Up - Vomiting is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Tissue Death - Tissue Necrosis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Ulcer of the Throat - Throat Ulceration is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Vasculitis is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Visible Water Retention - Edema is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Bile Flow Problems - Obstructive Hyperbilirubinemia is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Coumadin and Cymbalta combined

Click for a searchable interactive map of all Life Threatening Side Effects associated with Cymbalta and Coumadin combined.

Cymbalta and Coumadin Combined have 9 Most Frequently Occurring Side Effects

Chronic Trouble Sleeping - Insomnia is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Dizzy - Dizziness is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Drowsiness - Drowsy is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Dry Mouth - Xerostomia is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Excessive Sweating - Hyperhidrosis is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Incomplete or Infrequent Bowel Movements - Constipation is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Loss of Appetite - Anorexia is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Low Energy - Fatigue is a Frequently Occurring Side Effect of Cymbalta and Coumadin combined

Click for a searchable interactive map of all Side Effects associated with Cymbalta and Coumadin combined.

Cymbalta and Coumadin Drug-Drug Interactions

When combined Cymbalta and Coumadin have the following 1 Drug-Drug Interaction(s):

When combined Cymbalta and Coumadin have the following interaction of Serious seriousness: Concurrent administration of the selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors may result in increased levels of and effects from the anticoagulant.

Click for a searchable interactive map of all interactions between Cymbalta and Coumadin.

Cymbalta has 25 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Cymbalta.

Cymbalta Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Neuroleptic Malignant Syndrome is a contraindication of Cymbalta.

Serotonin Syndrome - Serotonin Syndrome - Adverse Drug Interaction is a contraindication of Cymbalta.

Relative Contraindications

Abnormal Hepatic Function Tests - Abnormal Liver Function Tests is a contraindication of Cymbalta.

Alcoholic Liver Damage - Hardening of the Liver caused by Alcohol is a contraindication of Cymbalta.

Alcoholism - Habit of Drinking Too Much Alcohol is a contraindication of Cymbalta.

Chronic Hepatitis - Chronic Inflammation of the Liver is a contraindication of Cymbalta.

Disease of Liver - Liver Problems is a contraindication of Cymbalta.

Hepatic Cirrhosis - Hardening of the Liver is a contraindication of Cymbalta.

Hepatitis is a contraindication of Cymbalta.

Jaundice - Yellowing of Skin or Eyes from Liver Problems is a contraindication of Cymbalta.

Narrow Angle Glaucoma - Closed Angle Glaucoma is a contraindication of Cymbalta.

Severe Renal Disease - Serious Kidney Problems is a contraindication of Cymbalta.

Suicidal Ideation - Having Thoughts of Suicide is a contraindication of Cymbalta.

Contraindication Warnings

Bipolar Disorder - Manic-Depression is a contraindication of Cymbalta.

Epilepsy - Epileptic Seizure is a contraindication of Cymbalta.

Gastrointestinal Hypomotility - Decreased Motility Function of Stomach or Intestines is a contraindication of Cymbalta.

Hyperglycemia - High Blood Sugar is a contraindication of Cymbalta.

Hypertension - High Blood Pressure is a contraindication of Cymbalta.

Hypomania - Mild Degree of Mania is a contraindication of Cymbalta.

Hyponatremia - Low Amount of Sodium in the Blood is a contraindication of Cymbalta.

Increased Risk of Bleeding is a contraindication of Cymbalta.

Manic Disorder - Behaving with Excessive Cheerfulness and Activity is a contraindication of Cymbalta.

Orthostatic Hypotension - Blood Pressure Drop Upon Standing is a contraindication of Cymbalta.

SIADH Syndrome - Syndrome of Inappropriate Antidiuretic Hormone Secretion is a contraindication of Cymbalta.

Urinary Retention - Cannot Empty Bladder is a contraindication of Cymbalta.

Coumadin has 60 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Coumadin.

Coumadin Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Aortic Aneurysm with Dissection - Bulge and Tear of the Aorta Blood Vessel Wall is a contraindication of Coumadin.

Bacterial Endocarditis - Bacterial Infection of Heart Valve is a contraindication of Coumadin.

Blood Coagulation Disorder - Blood Clotting Disorder is a contraindication of Coumadin.

Brain Aneurysm - Balloon-Like Swelling of an Artery of the Brain is a contraindication of Coumadin.

Cerebrovascular Hemorrhage - Hemorrhage in the Brain is a contraindication of Coumadin.

Eclampsia of Pregnancy - Seizures with Pregnancy is a contraindication of Coumadin.

Gastrointestinal Hemorrhage - Bleeding of the Stomach or Intestines is a contraindication of Coumadin.

Gastrointestinal Ulcer - Stomach or Intestinal Ulcer is a contraindication of Coumadin.

Genitourinary Tract Hemorrhage - Bleeding from the Genitourinary System is a contraindication of Coumadin.

Hemorrhage is a contraindication of Coumadin.

Internal Hemorrhage - Internal Bleeding is a contraindication of Coumadin.

Open Procedure on Central Nervous System - Operation on the Nervous System is a contraindication of Coumadin.

Pericardial Effusion - Fluid in the Covering of the Heart or Pericardium is a contraindication of Coumadin.

Pericarditis - Inflammation of the Covering of the Heart or Pericardium is a contraindication of Coumadin.

Pregnancy is a contraindication of Coumadin.

Respiratory Tract Hemorrhage - Bleeding from the Respiratory Tract is a contraindication of Coumadin.

Severe Uncontrolled Hypertension - Severe Uncontrolled High Blood Pressure is a contraindication of Coumadin.

Spinal Anesthesia - Local Anesthesia Injected into Spine is a contraindication of Coumadin.

Spinal Puncture - Spinal Tap is a contraindication of Coumadin.

Surgical Procedure on Eye Proper - Eye Surgery is a contraindication of Coumadin.

Threatened Abortion - Possibility of Having a Miscarriage is a contraindication of Coumadin.

Relative Contraindications

Alcoholism - Habit of Drinking Too Much Alcohol is a contraindication of Coumadin.

Cerebrovascular Disorder - Any Disorder of the Blood Vessels of the Brain is a contraindication of Coumadin.

Cholesterol Embolism - Obstruction of Blood Vessel caused by a Fat Globule is a contraindication of Coumadin.

Gangrene is a contraindication of Coumadin.

Heparin-Induced Thrombocytopenia - Decreased Platelets due to the Medication Heparin is a contraindication of Coumadin.

Increased Risk of Bleeding is a contraindication of Coumadin.

Indwelling Vascular Catheter - Patient with Catheter in the Vascular System is a contraindication of Coumadin.

Moderate Hypertension - Moderate High Blood Pressure is a contraindication of Coumadin.

Polycythemia Vera - Increased Red Blood Cells is a contraindication of Coumadin.

Protein C Deficiency Disease is a contraindication of Coumadin.

Psychotic Disorder - Mental Disorder with Loss of Normal Personality & Reality is a contraindication of Coumadin.

Renal Disease with Moderate to Severe Function Impairment - Moderate to Severe Kidney Impairment is a contraindication of Coumadin.

Secondary Uterine Inertia is a contraindication of Coumadin.

Severe Diabetes Mellitus - Severe Form of Diabetes is a contraindication of Coumadin.

Severe Hepatic Disease - Severe Liver Disease is a contraindication of Coumadin.

Severe and Chronic Diarrhea - Serious Loose Stools Lasting a Long Time is a contraindication of Coumadin.

Surgical Procedure - Recent Operation is a contraindication of Coumadin.

Tissue Necrosis - Tissue Death is a contraindication of Coumadin.

Trauma - Injury is a contraindication of Coumadin.

Tropical Sprue is a contraindication of Coumadin.

Vasculitis is a contraindication of Coumadin.

Vitamin K Deficiency - Inadequate Vitamin K is a contraindication of Coumadin.

Contraindication Warnings

Anemia is a contraindication of Coumadin.

Biliary Obstruction - Blockage of a Bile Duct is a contraindication of Coumadin.

Bleeding Risk Associated with Vitamin-K-Epoxide Reductase (Warfarin-Sensitive) Gene is a contraindication of Coumadin.

Connective Tissue Disease - Disorder of the Connective Tissue is a contraindication of Coumadin.

Disease of Liver - Liver Problems is a contraindication of Coumadin.

Edema - Visible Water Retention is a contraindication of Coumadin.

Fever is a contraindication of Coumadin.

Hyperlipidemia - High Amount of Fats in the Blood is a contraindication of Coumadin.

Hyperthyroidism - Overactive Thyroid Gland is a contraindication of Coumadin.

Hypothyroidism - Underactive Thyroid is a contraindication of Coumadin.

Malignancy - Malignant Tumor or Cancer is a contraindication of Coumadin.

Nephrotic Syndrome is a contraindication of Coumadin.

Nutritional Disorder - Poor Nutrition is a contraindication of Coumadin.

Poor Metabolizer due to Cytochrome p450 CYP2C9 Variant is a contraindication of Coumadin.

Severe Diarrhea is a contraindication of Coumadin.

Steatorrhea - Bowel Movements Containing Much Fat is a contraindication of Coumadin.

Viral Hepatitis - Viral Infection of the Liver is a contraindication of Coumadin.

Cymbalta - Symptoms of overdose may include
severe drowsiness, fainting.

Coumadin - Symptoms of overdose may include
bloody/black/tarry stools, pink/dark urine, unusual/prolonged bleeding.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.