Combine Cymbalta and Flexeril

Drug Interactions and Combined Side Effects of
Cymbalta

and Flexeril

Combine Cymbalta with Flexeril. To make a decision about taking Cymbalta and Flexeril, click here for a Medication Risk Map showing their individual and Combined Risks

Cymbalta and Flexeril have 105 combined Side Effects total
42 are Life Threatening
10 Occur Most Frequently

Click here for Drug Interactions and Side Effects of Cymbalta.
Click here for Drug Interactions and Side Effects of Flexeril.
Click here to compare Cymbalta vs Flexeril.

Uses of Cymbalta

Cymbalta is also known by the generic name Duloxetine

USES:
Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).

Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

Uses of Flexeril

Flexeril is also known by the generic name Cyclobenzaprine USES: This medication relaxes muscles. It is used along with rest and physical therapy to decrease muscle pain and spasms associated with strains, sprains or other muscle injuries.

Cymbalta and Flexeril Combined Have 42 Life Threatening (Major) Side Effects

Critcal Seriouosness - Abnormal Heart Rhythm - Conduction Disorder of the Heart is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Acute Infection of the Nose, Throat or Sinus - Upper Respiratory Infection is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Behaving with Excessive Cheerfulness and Activity - Manic Disorder is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Blockage of Normal Bile Flow - Cholestasis is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Bronchospasm - Bronchospastic Pulmonary Disease is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Bruise - Bruising is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Burning Stomach - Gastritis is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Confused - Impaired Cognition is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Depression is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Difficult or Painful Urination - Dysuria is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Fast Heartbeat - Tachyarrhythmia is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Feeling Faint - Fainting is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Giant Hives - Angioedema is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Having Thoughts of Suicide - Suicidal Ideation is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Hemorrhage of Blood Under the Skin - Ecchymosis is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Hemorrhage is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Hepatitis caused by Drugs - Drug-Induced Hepatitis is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Hepatitis is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Hives - Urticaria is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Mood Changes is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Needing to Urinate Immediately - Urinary Urgency is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Neuroleptic Malignant Syndrome is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Puffy Face from Water Retention - Facial Edema is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Rash - Skin Rash is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Reaction due to an Allergy - Allergic Reactions is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Red Blood in Bowel Movement - Bloody Stools is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Redness of Skin - Erythema is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Serotonin Syndrome - Adverse Drug Interaction - Serotonin Syndrome is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Stevens-Johnson Syndrome is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Stomach Cramps - Abdominal Pain with Cramps is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Stomach Ulcer - Gastric Ulcer is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Suicidal is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Syndrome of Inappropriate Antidiuretic Hormone Secretion - SIADH Syndrome is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Toxic Effect on Brain or Spinal Cord Function - CNS Toxicity is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Uncoordinated - Ataxia is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Bile Flow Problems - Obstructive Hyperbilirubinemia is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Flexeril and Cymbalta combined

Click for a searchable interactive map of all Life Threatening Side Effects associated with Cymbalta and Flexeril combined.

Cymbalta and Flexeril Combined have 10 Most Frequently Occurring Side Effects

Blurred Vision is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Chronic Trouble Sleeping - Insomnia is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Dizzy - Dizziness is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Drowsiness - Drowsy is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Dry Mouth - Xerostomia is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Excessive Sweating - Hyperhidrosis is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Incomplete or Infrequent Bowel Movements - Constipation is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Loss of Appetite - Anorexia is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Low Energy - Fatigue is a Frequently Occurring Side Effect of Cymbalta and Flexeril combined

Click for a searchable interactive map of all Side Effects associated with Cymbalta and Flexeril combined.

Cymbalta and Flexeril Drug-Drug Interactions

When combined Cymbalta and Flexeril have the following 1 Drug-Drug Interaction(s):

When combined Cymbalta and Flexeril have the following interaction of Moderate seriousness: Concurrent administration of a selective serotonin reuptake inhibitor, duloxetine or milnacipran with a tricyclic compound or trazodone may result in an increase in serum levels, toxicities, and/or clinical effects of the tricyclic compound or trazodone.

Click for a searchable interactive map of all interactions between Cymbalta and Flexeril.

Cymbalta has 25 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Cymbalta.

Cymbalta Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Neuroleptic Malignant Syndrome is a contraindication of Cymbalta.

Serotonin Syndrome - Serotonin Syndrome - Adverse Drug Interaction is a contraindication of Cymbalta.

Relative Contraindications

Abnormal Hepatic Function Tests - Abnormal Liver Function Tests is a contraindication of Cymbalta.

Alcoholic Liver Damage - Hardening of the Liver caused by Alcohol is a contraindication of Cymbalta.

Alcoholism - Habit of Drinking Too Much Alcohol is a contraindication of Cymbalta.

Chronic Hepatitis - Chronic Inflammation of the Liver is a contraindication of Cymbalta.

Disease of Liver - Liver Problems is a contraindication of Cymbalta.

Hepatic Cirrhosis - Hardening of the Liver is a contraindication of Cymbalta.

Hepatitis is a contraindication of Cymbalta.

Jaundice - Yellowing of Skin or Eyes from Liver Problems is a contraindication of Cymbalta.

Narrow Angle Glaucoma - Closed Angle Glaucoma is a contraindication of Cymbalta.

Severe Renal Disease - Serious Kidney Problems is a contraindication of Cymbalta.

Suicidal Ideation - Having Thoughts of Suicide is a contraindication of Cymbalta.

Contraindication Warnings

Bipolar Disorder - Manic-Depression is a contraindication of Cymbalta.

Epilepsy - Epileptic Seizure is a contraindication of Cymbalta.

Gastrointestinal Hypomotility - Decreased Motility Function of Stomach or Intestines is a contraindication of Cymbalta.

Hyperglycemia - High Blood Sugar is a contraindication of Cymbalta.

Hypertension - High Blood Pressure is a contraindication of Cymbalta.

Hypomania - Mild Degree of Mania is a contraindication of Cymbalta.

Hyponatremia - Low Amount of Sodium in the Blood is a contraindication of Cymbalta.

Increased Risk of Bleeding is a contraindication of Cymbalta.

Manic Disorder - Behaving with Excessive Cheerfulness and Activity is a contraindication of Cymbalta.

Orthostatic Hypotension - Blood Pressure Drop Upon Standing is a contraindication of Cymbalta.

SIADH Syndrome - Syndrome of Inappropriate Antidiuretic Hormone Secretion is a contraindication of Cymbalta.

Urinary Retention - Cannot Empty Bladder is a contraindication of Cymbalta.

Flexeril has 10 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Flexeril.

Flexeril Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Chronic Heart Failure is a contraindication of Flexeril.

Conduction Disorder of the Heart - Abnormal Heart Rhythm is a contraindication of Flexeril.

Heart Block is a contraindication of Flexeril.

Hyperthyroidism - Overactive Thyroid Gland is a contraindication of Flexeril.

Recovery Phase Following Myocardial Infarct - Recent Heart Attack is a contraindication of Flexeril.

Relative Contraindications

Severe Hepatic Disease - Severe Liver Disease is a contraindication of Flexeril.

Sinus Tachycardia is a contraindication of Flexeril.

Contraindication Warnings

Glaucoma - Increased Pressure in Eyes is a contraindication of Flexeril.

Open Angle Glaucoma - Wide-Angle Glaucoma is a contraindication of Flexeril.

Urinary Retention - Cannot Empty Bladder is a contraindication of Flexeril.

Cymbalta - Symptoms of overdose may include
severe drowsiness, fainting.

Flexeril - Symptoms of overdose may include
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include severe drowsiness, fast heartbeat, slurred speech, hallucinations, chest pain, seizures, increased muscle stiffness with fever and sweating,

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.