Combine Depakote and Warfarin

Drug Interactions and Combined Side Effects of
Depakote

and Warfarin

Combine Depakote with Warfarin. To make a decision about taking Depakote and Warfarin, click here for a Medication Risk Map showing their individual and Combined Risks

Depakote and Warfarin have 91 combined Side Effects total
54 are Life Threatening
17 Occur Most Frequently

Click here for Drug Interactions and Side Effects of Depakote.
Click here for Drug Interactions and Side Effects of Warfarin.
Click here to compare Depakote vs Warfarin.

Uses of Depakote

Depakote is also known by the generic name Divalproex USES: This medication is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Uses of Warfarin

USES:
This medication is used to treat blood clots (such as in deep vein thrombosis-DVT or pulmonary embolus-PE) and/or to prevent new clots from forming in your body. Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack. Conditions that increase your risk of developing blood clots include a certain type of irregular heart rhythm (atrial fibrillation), heart valve replacement, recent heart attack, and certain surgeries (such as hip/knee replacement).

Warfarin is commonly called a "blood thinner," but the more correct term is "anticoagulant." It helps to keep blood flowing smoothly in your body by decreasing the amount of certain substances (clotting proteins) in your blood.

Depakote and Warfarin Combined Have 54 Life Threatening (Major) Side Effects

Critcal Seriouosness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Acute Inflammation of the Pancreas - Acute Pancreatitis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Acute Liver Failure - Acute Hepatic Failure is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Adrenal Hemorrhage is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Allergic Reaction caused by a Drug - Hypersensitivity Drug Reactions is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Bloody Urine - Hematuria is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Canker Sore - Aphthous Stomatitis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Decrease in the Ability of Platelet Cells to Clot - Platelet Aggregation Inhibition is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Decreased Blood Platelets - Thrombocytopenic Disorder is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Decreased White Blood Cells - Leukopenia is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Deficiency of Granulocytes a Type of White Blood Cell - Agranulocytosis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Diarrhea is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Double Vision - Diplopia is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Feel Like Throwing Up - Nausea is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Fluid Retention in the Legs, Feet, Arms or Hands - Peripheral Edema is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Foot Pain - Feet Pain is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Gangrene is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Having Thoughts of Suicide - Suicidal Ideation is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Hemorrhage is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Hepatitis caused by Drugs - Drug-Induced Hepatitis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - High Amount of Ammonium in the Blood - Hyperammonemia is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - High Blood Pressure - Hypertension is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Hives - Urticaria is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Increased Risk of Bleeding is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Inflammation of the Liver with Stoppage of Bile Flow - Cholestatic Hepatitis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Involuntary Eye Movement - Nystagmus is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Kidney Disease - Renal Disease is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Lack of Blood Supply to the Brain - Cerebral Ischemia is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Low Body Temperature - Hypothermia is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Mental Impairment is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Mood Changes is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Muscle Pain - Myalgia is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Numbness and Tingling - Paresthesia is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Obstruction of Blood Vessel caused by a Fat Globule - Cholesterol Embolism is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Pain in Arms or Legs - Limb Pain is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Pancreatitis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Problem Behavior - Behavioral Disorders is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Problem with Adrenal Gland - Acute Adrenocortical Insufficiency is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Puffy Face from Water Retention - Facial Edema is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Purplish Discoloration of the Skin that Looks Like Netting - Livedo Reticularis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Rash - Skin Rash is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Seeing Spots - Visual Disturbance of Seeing Spots is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Stomach Cramps - Abdominal Pain with Cramps is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Swollen Lymph Nodes - Lymphadenopathy is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Throwing Up - Vomiting is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Tissue Death - Tissue Necrosis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Ulcer of the Throat - Throat Ulceration is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Vasculitis is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Visible Water Retention - Edema is a Life Threatening Side Effect of Warfarin and Depakote combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Warfarin and Depakote combined

Click for a searchable interactive map of all Life Threatening Side Effects associated with Depakote and Warfarin combined.

Depakote and Warfarin Combined have 17 Most Frequently Occurring Side Effects

Chronic Trouble Sleeping - Insomnia is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Diarrhea is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Dizzy - Dizziness is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Drowsiness - Drowsy is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Hair Loss - Alopecia is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Indigestion - Dyspepsia is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Infection is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Involuntary Quivering - Tremors is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Irregular Periods - Irregular Menstrual Periods is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Loss of Appetite - Anorexia is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Ringing in the Ears - Tinnitus is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Stomach Cramps - Abdominal Pain with Cramps is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Throat Irritation - Pharyngitis is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Throwing Up - Vomiting is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Weight Gain is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Weight Loss is a Frequently Occurring Side Effect of Depakote and Warfarin combined

Click for a searchable interactive map of all Side Effects associated with Depakote and Warfarin combined.

Depakote and Warfarin Drug-Drug Interactions

There are no drug-drug interactions between Depakote and Warfarin.

Depakote has 16 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Depakote.

Depakote Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Acute Pancreatitis - Acute Inflammation of the Pancreas is a contraindication of Depakote.

Carbamyl Phosphate Synthetase Deficiency - Inherited Deficiency of Carbamyl Phosphate Synthetase is a contraindication of Depakote.

Chronic Pancreatitis - Chronic Inflammation of the Pancreas is a contraindication of Depakote.

Disease of Liver - Liver Problems is a contraindication of Depakote.

Ornithine Carbamyltransferase Deficiency is a contraindication of Depakote.

Pregnancy is a contraindication of Depakote.

Relative Contraindications

Hyperammonemia - High Amount of Ammonium in the Blood is a contraindication of Depakote.

Porphyria is a contraindication of Depakote.

Thrombocytopenic Disorder - Decreased Blood Platelets is a contraindication of Depakote.

Contraindication Warnings

Blood Dyscrasias - Blood Disorder is a contraindication of Depakote.

Depression is a contraindication of Depakote.

Hypoalbuminemia - Low Amount of Albumin Proteins in the Blood is a contraindication of Depakote.

Organic Mental Disorder - Dysfunction of the Brain is a contraindication of Depakote.

Renal Disease - Kidney Disease is a contraindication of Depakote.

Suicidal Ideation - Having Thoughts of Suicide is a contraindication of Depakote.

Valproic Acid Toxicity - Poisoning by Drug Valproic Acid is a contraindication of Depakote.

Warfarin has 60 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Warfarin.

Warfarin Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Aortic Aneurysm with Dissection - Bulge and Tear of the Aorta Blood Vessel Wall is a contraindication of Warfarin.

Bacterial Endocarditis - Bacterial Infection of Heart Valve is a contraindication of Warfarin.

Blood Coagulation Disorder - Blood Clotting Disorder is a contraindication of Warfarin.

Brain Aneurysm - Balloon-Like Swelling of an Artery of the Brain is a contraindication of Warfarin.

Cerebrovascular Hemorrhage - Hemorrhage in the Brain is a contraindication of Warfarin.

Eclampsia of Pregnancy - Seizures with Pregnancy is a contraindication of Warfarin.

Gastrointestinal Hemorrhage - Bleeding of the Stomach or Intestines is a contraindication of Warfarin.

Gastrointestinal Ulcer - Stomach or Intestinal Ulcer is a contraindication of Warfarin.

Genitourinary Tract Hemorrhage - Bleeding from the Genitourinary System is a contraindication of Warfarin.

Hemorrhage is a contraindication of Warfarin.

Internal Hemorrhage - Internal Bleeding is a contraindication of Warfarin.

Open Procedure on Central Nervous System - Operation on the Nervous System is a contraindication of Warfarin.

Pericardial Effusion - Fluid in the Covering of the Heart or Pericardium is a contraindication of Warfarin.

Pericarditis - Inflammation of the Covering of the Heart or Pericardium is a contraindication of Warfarin.

Pregnancy is a contraindication of Warfarin.

Respiratory Tract Hemorrhage - Bleeding from the Respiratory Tract is a contraindication of Warfarin.

Severe Uncontrolled Hypertension - Severe Uncontrolled High Blood Pressure is a contraindication of Warfarin.

Spinal Anesthesia - Local Anesthesia Injected into Spine is a contraindication of Warfarin.

Spinal Puncture - Spinal Tap is a contraindication of Warfarin.

Surgical Procedure on Eye Proper - Eye Surgery is a contraindication of Warfarin.

Threatened Abortion - Possibility of Having a Miscarriage is a contraindication of Warfarin.

Relative Contraindications

Alcoholism - Habit of Drinking Too Much Alcohol is a contraindication of Warfarin.

Cerebrovascular Disorder - Any Disorder of the Blood Vessels of the Brain is a contraindication of Warfarin.

Cholesterol Embolism - Obstruction of Blood Vessel caused by a Fat Globule is a contraindication of Warfarin.

Gangrene is a contraindication of Warfarin.

Heparin-Induced Thrombocytopenia - Decreased Platelets due to the Medication Heparin is a contraindication of Warfarin.

Increased Risk of Bleeding is a contraindication of Warfarin.

Indwelling Vascular Catheter - Patient with Catheter in the Vascular System is a contraindication of Warfarin.

Moderate Hypertension - Moderate High Blood Pressure is a contraindication of Warfarin.

Polycythemia Vera - Increased Red Blood Cells is a contraindication of Warfarin.

Protein C Deficiency Disease is a contraindication of Warfarin.

Psychotic Disorder - Mental Disorder with Loss of Normal Personality & Reality is a contraindication of Warfarin.

Renal Disease with Moderate to Severe Function Impairment - Moderate to Severe Kidney Impairment is a contraindication of Warfarin.

Secondary Uterine Inertia is a contraindication of Warfarin.

Severe Diabetes Mellitus - Severe Form of Diabetes is a contraindication of Warfarin.

Severe Hepatic Disease - Severe Liver Disease is a contraindication of Warfarin.

Severe and Chronic Diarrhea - Serious Loose Stools Lasting a Long Time is a contraindication of Warfarin.

Surgical Procedure - Recent Operation is a contraindication of Warfarin.

Tissue Necrosis - Tissue Death is a contraindication of Warfarin.

Trauma - Injury is a contraindication of Warfarin.

Tropical Sprue is a contraindication of Warfarin.

Vasculitis is a contraindication of Warfarin.

Vitamin K Deficiency - Inadequate Vitamin K is a contraindication of Warfarin.

Contraindication Warnings

Anemia is a contraindication of Warfarin.

Biliary Obstruction - Blockage of a Bile Duct is a contraindication of Warfarin.

Bleeding Risk Associated with Vitamin-K-Epoxide Reductase (Warfarin-Sensitive) Gene is a contraindication of Warfarin.

Connective Tissue Disease - Disorder of the Connective Tissue is a contraindication of Warfarin.

Disease of Liver - Liver Problems is a contraindication of Warfarin.

Edema - Visible Water Retention is a contraindication of Warfarin.

Fever is a contraindication of Warfarin.

Hyperlipidemia - High Amount of Fats in the Blood is a contraindication of Warfarin.

Hyperthyroidism - Overactive Thyroid Gland is a contraindication of Warfarin.

Hypothyroidism - Underactive Thyroid is a contraindication of Warfarin.

Malignancy - Malignant Tumor or Cancer is a contraindication of Warfarin.

Nephrotic Syndrome is a contraindication of Warfarin.

Nutritional Disorder - Poor Nutrition is a contraindication of Warfarin.

Poor Metabolizer due to Cytochrome p450 CYP2C9 Variant is a contraindication of Warfarin.

Severe Diarrhea is a contraindication of Warfarin.

Steatorrhea - Bowel Movements Containing Much Fat is a contraindication of Warfarin.

Viral Hepatitis - Viral Infection of the Liver is a contraindication of Warfarin.

Depakote - Symptoms of overdose may include
excessive drowsiness, coma, irregular/slowed/skipped heart beats (heart block).

Warfarin - Symptoms of overdose may include
bloody/black/tarry stools, pink/dark urine, unusual/prolonged bleeding.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.