Combine Depakote and Zoloft

Drug Interactions and Combined Side Effects of
Depakote

and Zoloft

Combine Depakote with Zoloft. To make a decision about taking Depakote and Zoloft, click here for a Medication Risk Map showing their individual and Combined Risks

Depakote and Zoloft have 83 combined Side Effects total
42 are Life Threatening
28 Occur Most Frequently

Click here for Drug Interactions and Side Effects of Depakote.
Click here for Drug Interactions and Side Effects of Zoloft.
Click here to compare Depakote vs Zoloft.

Uses of Depakote

Depakote is also known by the generic name Divalproex USES: This medication is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Uses of Zoloft

Zoloft is also known by the generic name Sertraline

USES:
Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).

This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. Sertraline is known as a selective serotonin reuptake inhibitor (SSRI). It works by helping to restore the balance of a certain natural substance (serotonin) in the brain.

Depakote and Zoloft Combined Have 42 Life Threatening (Major) Side Effects

Critcal Seriouosness - A Feeling of Restlessness with Inability to Sit Still - Akathisia is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Acute Inflammation of the Pancreas - Acute Pancreatitis is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Acute Liver Failure - Acute Hepatic Failure is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Altered Interest in Having Sexual Intercourse - Libido Changes is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Behaving with Excessive Cheerfulness and Activity - Manic Disorder is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Bleeding of the Stomach or Intestines - Gastrointestinal Hemorrhage is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Breast Tenderness - Mastalgia is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Decrease in the Ability of Platelet Cells to Clot - Platelet Aggregation Inhibition is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Decreased Blood Platelets - Thrombocytopenic Disorder is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Discharge of Milk in Men or Women when Not Breastfeeding - Galactorrhea not associated with Childbirth is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Double Vision - Diplopia is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Extrapyramidal Reaction - Extrapyramidal Disease is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Fever is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Fluid Retention in the Legs, Feet, Arms or Hands - Peripheral Edema is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Having Thoughts of Suicide - Suicidal Ideation is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Heart Throbbing or Pounding - Palpitations is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Hemorrhage is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Hepatitis caused by Drugs - Drug-Induced Hepatitis is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - High Amount of Ammonium in the Blood - Hyperammonemia is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Hives - Urticaria is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Inability to have an Erection - Erectile Dysfunction is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Involuntary Eye Movement - Nystagmus is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Low Amount of Sodium in the Blood - Hyponatremia is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Low Body Temperature - Hypothermia is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Mental Impairment is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Mild Degree of Mania - Hypomania is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Mood Changes is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Neuroleptic Malignant Syndrome is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Nosebleed - Epistaxis is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Problem Behavior - Behavioral Disorders is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Puffy Face from Water Retention - Facial Edema is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Rash - Skin Rash is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Reaction due to an Allergy - Allergic Reactions is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Seeing Spots - Visual Disturbance of Seeing Spots is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Serotonin Syndrome - Adverse Drug Interaction - Serotonin Syndrome is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Sexual Problems - Abnormal Sexual Function is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Swollen Lymph Nodes - Lymphadenopathy is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Zoloft and Depakote combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Zoloft and Depakote combined

Click for a searchable interactive map of all Life Threatening Side Effects associated with Depakote and Zoloft combined.

Depakote and Zoloft Combined have 28 Most Frequently Occurring Side Effects

Altered Interest in Having Sexual Intercourse - Libido Changes is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Chronic Trouble Sleeping - Insomnia is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Diarrhea is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Dizzy - Dizziness is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Drowsiness - Drowsy is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Dry Mouth - Xerostomia is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Excessive Sweating - Hyperhidrosis is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Feeling Weak - General Weakness is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Gas - Flatulence is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Hair Loss - Alopecia is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Head Pain - Headache Disorder is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Inability to have an Erection - Erectile Dysfunction is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Incomplete or Infrequent Bowel Movements - Constipation is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Indigestion - Dyspepsia is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Infection is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Involuntary Quivering - Tremors is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Irregular Periods - Irregular Menstrual Periods is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Loss of Appetite - Anorexia is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Low Energy - Fatigue is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Nervous - Nervousness is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Ringing in the Ears - Tinnitus is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Sexual Problems - Abnormal Sexual Function is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Stomach Cramps - Abdominal Pain with Cramps is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Throat Irritation - Pharyngitis is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Throwing Up - Vomiting is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Weight Gain is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Weight Loss is a Frequently Occurring Side Effect of Depakote and Zoloft combined

Click for a searchable interactive map of all Side Effects associated with Depakote and Zoloft combined.

Depakote and Zoloft Drug-Drug Interactions

There are no drug-drug interactions between Depakote and Zoloft.

Depakote has 16 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Depakote.

Depakote Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Acute Pancreatitis - Acute Inflammation of the Pancreas is a contraindication of Depakote.

Carbamyl Phosphate Synthetase Deficiency - Inherited Deficiency of Carbamyl Phosphate Synthetase is a contraindication of Depakote.

Chronic Pancreatitis - Chronic Inflammation of the Pancreas is a contraindication of Depakote.

Disease of Liver - Liver Problems is a contraindication of Depakote.

Ornithine Carbamyltransferase Deficiency is a contraindication of Depakote.

Pregnancy is a contraindication of Depakote.

Relative Contraindications

Hyperammonemia - High Amount of Ammonium in the Blood is a contraindication of Depakote.

Porphyria is a contraindication of Depakote.

Thrombocytopenic Disorder - Decreased Blood Platelets is a contraindication of Depakote.

Contraindication Warnings

Blood Dyscrasias - Blood Disorder is a contraindication of Depakote.

Depression is a contraindication of Depakote.

Hypoalbuminemia - Low Amount of Albumin Proteins in the Blood is a contraindication of Depakote.

Organic Mental Disorder - Dysfunction of the Brain is a contraindication of Depakote.

Renal Disease - Kidney Disease is a contraindication of Depakote.

Suicidal Ideation - Having Thoughts of Suicide is a contraindication of Depakote.

Valproic Acid Toxicity - Poisoning by Drug Valproic Acid is a contraindication of Depakote.

Zoloft has 13 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Zoloft.

Zoloft Oral Contraindications
(grouped by decreasing seriousness level)

Relative Contraindications

Bipolar Disorder - Manic-Depression is a contraindication of Zoloft.

Neuroleptic Malignant Syndrome is a contraindication of Zoloft.

Serotonin Syndrome - Serotonin Syndrome - Adverse Drug Interaction is a contraindication of Zoloft.

Suicidal Ideation - Having Thoughts of Suicide is a contraindication of Zoloft.

Upper GI Bleed - Bleeding from Stomach, Esophagus or Duodenum is a contraindication of Zoloft.

Contraindication Warnings

Disease of Liver - Liver Problems is a contraindication of Zoloft.

Hypomania - Mild Degree of Mania is a contraindication of Zoloft.

Hyponatremia - Low Amount of Sodium in the Blood is a contraindication of Zoloft.

Increased Risk of Bleeding is a contraindication of Zoloft.

Manic Disorder - Behaving with Excessive Cheerfulness and Activity is a contraindication of Zoloft.

SIADH Syndrome - Syndrome of Inappropriate Antidiuretic Hormone Secretion is a contraindication of Zoloft.

Seizure Disorder - Seizures is a contraindication of Zoloft.

Weight Loss is a contraindication of Zoloft.

Depakote - Symptoms of overdose may include
excessive drowsiness, coma, irregular/slowed/skipped heart beats (heart block).

Zoloft - Symptoms of overdose may include
severe dizziness, fainting.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.