Combine Plavix and Coumadin

Drug Interactions and Combined Side Effects of
Plavix

and Coumadin

Combine Plavix with Coumadin. To make a decision about taking Plavix and Coumadin, click here for a Medication Risk Map showing their individual and Combined Risks

Plavix and Coumadin have 90 combined Side Effects total
66 are Life Threatening
2 Occur Most Frequently

Click here for Drug Interactions and Side Effects of Plavix.
Click here for Drug Interactions and Side Effects of Coumadin.
Click here to compare Plavix vs Coumadin.

Uses of Plavix

Plavix is also known by the generic name Clopidogrel

USES:
Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).

It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent, coronary artery bypass graft-CABG, balloon angioplasty).

It works by blocking certain blood cells called platelets and prevents them from forming harmful blood clots. This "anti-platelet" effect helps keep blood flowing smoothly in your body.

Uses of Coumadin

Coumadin is also known by the generic name Warfarin

USES:
This medication is used to treat blood clots (such as in deep vein thrombosis-DVT or pulmonary embolus-PE) and/or to prevent new clots from forming in your body. Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack. Conditions that increase your risk of developing blood clots include a certain type of irregular heart rhythm (atrial fibrillation), heart valve replacement, recent heart attack, and certain surgeries (such as hip/knee replacement).

Warfarin is commonly called a "blood thinner," but the more correct term is "anticoagulant." It helps to keep blood flowing smoothly in your body by decreasing the amount of certain substances (clotting proteins) in your blood.

Plavix and Coumadin Combined Have 66 Life Threatening (Major) Side Effects

Critcal Seriouosness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Abnormally Low Blood Pressure - Hypotension is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Acquired Decrease of All Cells in the Blood - Pancytopenia is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Acute Liver Failure - Acute Hepatic Failure is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Adrenal Hemorrhage is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Allergic Reaction caused by a Drug - Hypersensitivity Drug Reactions is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Allergic Reaction causing Serum Sickness - Serum Sickness is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Bleeding from Wound is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Bleeding from the Respiratory Tract - Respiratory Tract Hemorrhage is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Bleeding in the Abdomen - Retroperitoneal Hemorrhage is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Bleeding of the Stomach or Intestines - Gastrointestinal Hemorrhage is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Bloody Urine - Hematuria is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Bronchospasm - Bronchospastic Pulmonary Disease is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Canker Sore - Aphthous Stomatitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Confused - Impaired Cognition is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Decreased Blood Platelets - Thrombocytopenic Disorder is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Decreased White Blood Cells - Leukopenia is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Deficiency of Granulocytes a Type of White Blood Cell - Agranulocytosis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Diarrhea is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Erythema Multiforme is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Eye Hemorrhage - Ocular Bleeding is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Feel Like Throwing Up - Nausea is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Foot Pain - Feet Pain is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Gangrene is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Giant Hives - Angioedema is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Hallucination - Hallucinations is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Hemorrhage Within the Skull - Intracranial Bleeding is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Hemorrhage from the Conjunctiva of the Eye - Conjunctival Hemorrhage is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Hemorrhage is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Hepatitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - High Blood Pressure - Hypertension is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Hives - Urticaria is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Increased Risk of Bleeding is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Inflammation of the Large Intestine - Colitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Inflammation of the Liver with Stoppage of Bile Flow - Cholestatic Hepatitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Inflammation of the Skin with Blisters - Bullous Dermatitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Interstitial Pneumonitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Kidney Disease - Renal Disease is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Lack of Blood Supply to the Brain - Cerebral Ischemia is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Low Blood Counts due to Bone Marrow Failure - Aplastic Anemia is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Muscle Pain - Myalgia is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Nosebleed - Epistaxis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Numbness and Tingling - Paresthesia is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Obstruction of Blood Vessel caused by a Fat Globule - Cholesterol Embolism is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Pain in Arms or Legs - Limb Pain is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Painful, Red or Swollen Mouth - Stomatitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Pancreatitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Problem with Adrenal Gland - Acute Adrenocortical Insufficiency is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Purplish Discoloration of the Skin that Looks Like Netting - Livedo Reticularis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Rash - Skin Rash is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Retinal Hemorrhage is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Stevens-Johnson Syndrome is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Stomach Cramps - Abdominal Pain with Cramps is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Stomach Ulcer - Gastric Ulcer is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Thrombotic Thrombocytopenic Purpura is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Throwing Up - Vomiting is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Tissue Death - Tissue Necrosis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Toxic Epidermal Necrolysis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Ulcer of the Duodenum - Duodenal Ulcer is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Ulcer of the Throat - Throat Ulceration is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Vasculitis is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Visible Water Retention - Edema is a Life Threatening Side Effect of Coumadin and Plavix combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Coumadin and Plavix combined

Click for a searchable interactive map of all Life Threatening Side Effects associated with Plavix and Coumadin combined.

Plavix and Coumadin Combined have 2 Most Frequently Occurring Side Effects

Head Pain - Headache Disorder is a Frequently Occurring Side Effect of Plavix and Coumadin combined Joint Pain - Arthralgia is a Frequently Occurring Side Effect of Plavix and Coumadin combined Click for a searchable interactive map of all Side Effects associated with Plavix and Coumadin combined.

Plavix and Coumadin Drug-Drug Interactions

When combined Plavix and Coumadin have the following 2 Drug-Drug Interaction(s): When combined Plavix and Coumadin have the following interaction of Moderate seriousness: The concurrent use of platelet aggregation inhibitors and anticoagulants may result in an increased risk of bleeding. Click for a searchable interactive map of all interactions between Plavix and Coumadin.

Plavix has 12 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Plavix.

Plavix Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Acute Hemorrhage is a contraindication of Plavix.

Gastrointestinal Hemorrhage - Bleeding of the Stomach or Intestines is a contraindication of Plavix.

Intracranial Bleeding - Hemorrhage Within the Skull is a contraindication of Plavix.

Relative Contraindications

Blood Coagulation Disorder - Blood Clotting Disorder is a contraindication of Plavix.

Gastrointestinal Ulcer - Stomach or Intestinal Ulcer is a contraindication of Plavix.

Poor Metabolizer due to Cytochrome p450 CYP2C19 Variant is a contraindication of Plavix.

Retinal Hemorrhage is a contraindication of Plavix.

Surgical Procedure - Recent Operation is a contraindication of Plavix.

Thrombotic Thrombocytopenic Purpura is a contraindication of Plavix.

Contraindication Warnings

Increased Risk of Bleeding is a contraindication of Plavix.

Severe Renal Disease - Serious Kidney Problems is a contraindication of Plavix.

Trauma - Injury is a contraindication of Plavix.

Coumadin has 60 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Coumadin.

Coumadin Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Aortic Aneurysm with Dissection - Bulge and Tear of the Aorta Blood Vessel Wall is a contraindication of Coumadin.

Bacterial Endocarditis - Bacterial Infection of Heart Valve is a contraindication of Coumadin.

Blood Coagulation Disorder - Blood Clotting Disorder is a contraindication of Coumadin.

Brain Aneurysm - Balloon-Like Swelling of an Artery of the Brain is a contraindication of Coumadin.

Cerebrovascular Hemorrhage - Hemorrhage in the Brain is a contraindication of Coumadin.

Eclampsia of Pregnancy - Seizures with Pregnancy is a contraindication of Coumadin.

Gastrointestinal Hemorrhage - Bleeding of the Stomach or Intestines is a contraindication of Coumadin.

Gastrointestinal Ulcer - Stomach or Intestinal Ulcer is a contraindication of Coumadin.

Genitourinary Tract Hemorrhage - Bleeding from the Genitourinary System is a contraindication of Coumadin.

Hemorrhage is a contraindication of Coumadin.

Internal Hemorrhage - Internal Bleeding is a contraindication of Coumadin.

Open Procedure on Central Nervous System - Operation on the Nervous System is a contraindication of Coumadin.

Pericardial Effusion - Fluid in the Covering of the Heart or Pericardium is a contraindication of Coumadin.

Pericarditis - Inflammation of the Covering of the Heart or Pericardium is a contraindication of Coumadin.

Pregnancy is a contraindication of Coumadin.

Respiratory Tract Hemorrhage - Bleeding from the Respiratory Tract is a contraindication of Coumadin.

Severe Uncontrolled Hypertension - Severe Uncontrolled High Blood Pressure is a contraindication of Coumadin.

Spinal Anesthesia - Local Anesthesia Injected into Spine is a contraindication of Coumadin.

Spinal Puncture - Spinal Tap is a contraindication of Coumadin.

Surgical Procedure on Eye Proper - Eye Surgery is a contraindication of Coumadin.

Threatened Abortion - Possibility of Having a Miscarriage is a contraindication of Coumadin.

Relative Contraindications

Alcoholism - Habit of Drinking Too Much Alcohol is a contraindication of Coumadin.

Cerebrovascular Disorder - Any Disorder of the Blood Vessels of the Brain is a contraindication of Coumadin.

Cholesterol Embolism - Obstruction of Blood Vessel caused by a Fat Globule is a contraindication of Coumadin.

Gangrene is a contraindication of Coumadin.

Heparin-Induced Thrombocytopenia - Decreased Platelets due to the Medication Heparin is a contraindication of Coumadin.

Increased Risk of Bleeding is a contraindication of Coumadin.

Indwelling Vascular Catheter - Patient with Catheter in the Vascular System is a contraindication of Coumadin.

Moderate Hypertension - Moderate High Blood Pressure is a contraindication of Coumadin.

Polycythemia Vera - Increased Red Blood Cells is a contraindication of Coumadin.

Protein C Deficiency Disease is a contraindication of Coumadin.

Psychotic Disorder - Mental Disorder with Loss of Normal Personality & Reality is a contraindication of Coumadin.

Renal Disease with Moderate to Severe Function Impairment - Moderate to Severe Kidney Impairment is a contraindication of Coumadin.

Secondary Uterine Inertia is a contraindication of Coumadin.

Severe Diabetes Mellitus - Severe Form of Diabetes is a contraindication of Coumadin.

Severe Hepatic Disease - Severe Liver Disease is a contraindication of Coumadin.

Severe and Chronic Diarrhea - Serious Loose Stools Lasting a Long Time is a contraindication of Coumadin.

Surgical Procedure - Recent Operation is a contraindication of Coumadin.

Tissue Necrosis - Tissue Death is a contraindication of Coumadin.

Trauma - Injury is a contraindication of Coumadin.

Tropical Sprue is a contraindication of Coumadin.

Vasculitis is a contraindication of Coumadin.

Vitamin K Deficiency - Inadequate Vitamin K is a contraindication of Coumadin.

Contraindication Warnings

Anemia is a contraindication of Coumadin.

Biliary Obstruction - Blockage of a Bile Duct is a contraindication of Coumadin.

Bleeding Risk Associated with Vitamin-K-Epoxide Reductase (Warfarin-Sensitive) Gene is a contraindication of Coumadin.

Connective Tissue Disease - Disorder of the Connective Tissue is a contraindication of Coumadin.

Disease of Liver - Liver Problems is a contraindication of Coumadin.

Edema - Visible Water Retention is a contraindication of Coumadin.

Fever is a contraindication of Coumadin.

Hyperlipidemia - High Amount of Fats in the Blood is a contraindication of Coumadin.

Hyperthyroidism - Overactive Thyroid Gland is a contraindication of Coumadin.

Hypothyroidism - Underactive Thyroid is a contraindication of Coumadin.

Malignancy - Malignant Tumor or Cancer is a contraindication of Coumadin.

Nephrotic Syndrome is a contraindication of Coumadin.

Nutritional Disorder - Poor Nutrition is a contraindication of Coumadin.

Poor Metabolizer due to Cytochrome p450 CYP2C9 Variant is a contraindication of Coumadin.

Severe Diarrhea is a contraindication of Coumadin.

Steatorrhea - Bowel Movements Containing Much Fat is a contraindication of Coumadin.

Viral Hepatitis - Viral Infection of the Liver is a contraindication of Coumadin.

Plavix - Symptoms of overdose may include
If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

Coumadin - Symptoms of overdose may include
bloody/black/tarry stools, pink/dark urine, unusual/prolonged bleeding.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.