Combine Zofran and Promethazine

Drug Interactions and Combined Side Effects of
Zofran

and Promethazine

Combine Zofran with Promethazine. To make a decision about taking Zofran and Promethazine, click here for a Medication Risk Map showing their individual and Combined Risks

Zofran and Promethazine have 74 combined Side Effects total
31 are Life Threatening
21 Occur Most Frequently

Click here for Drug Interactions and Side Effects of Zofran.
Click here for Drug Interactions and Side Effects of Promethazine.
Click here to compare Zofran vs Promethazine.

Uses of Zofran

Zofran is also known by the generic name Ondansetron Hcl USES: This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Uses of Promethazine

USES:
Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (e.g., motion sickness, before/after surgery). It is also used to treat allergic symptoms such as rash, itching, and runny nose. It may be used for a short time to treat a runny nose due to the common cold. It may also be used to help you feel calmer before/after surgery or to help certain narcotic pain relievers (e.g., meperidine) work better.

Promethazine is an antihistamine. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (e.g., anti-nausea, calming, pain relief) may work by affecting other natural substances (e.g., acetylcholine) and by acting directly on certain parts of the brain.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

Zofran and Promethazine Combined Have 31 Life Threatening (Major) Side Effects

Critcal Seriouosness - Abnormal Heart Rhythm - Conduction Disorder of the Heart is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Abnormally Low Blood Pressure - Hypotension is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Acute Liver Failure - Acute Hepatic Failure is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Asthma - Bronchial Asthma is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Blurred Vision is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Bronchospasm - Bronchospastic Pulmonary Disease is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Decreased Blood Platelets - Thrombocytopenic Disorder is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Decreased Oxygen In The Tissues Or Blood - Hypoxia is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Decreased White Blood Cells - Leukopenia is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Deficiency of Granulocytes a Type of White Blood Cell - Agranulocytosis is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Delirium is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Extrapyramidal Reaction - Extrapyramidal Disease is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Feeling Faint - Fainting is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Giant Hives - Angioedema is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Hallucination - Hallucinations is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - High Blood Pressure - Hypertension is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Hives - Urticaria is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Lower Seizure Threshold is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Neuroleptic Malignant Syndrome is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Periods of Not Breathing - Apnea is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Shock is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Significant Decrease in Lung Function - Respiratory Depression is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Slow Heartbeat - Bradycardia is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Temporary Blindness - Transient Blindness is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Thrombotic Thrombocytopenic Purpura is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Vocal Cord Swelling - Laryngeal Edema is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Bile Flow Problems - Obstructive Hyperbilirubinemia is a Life Threatening Side Effect of Promethazine and Zofran combined

Critcal Seriouosness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Promethazine and Zofran combined

Click for a searchable interactive map of all Life Threatening Side Effects associated with Zofran and Promethazine combined.

Zofran and Promethazine Combined have 21 Most Frequently Occurring Side Effects

Abnormally Low Blood Pressure - Hypotension is a Frequently Occurring Side Effect of Zofran and Promethazine combined

An Increase in the Thickness of Lung Secretions - Thick Bronchial Secretions is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Blurred Vision is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Chills is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Confused - Impaired Cognition is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Diarrhea is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Dizzy - Dizziness is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Drowsiness - Drowsy is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Dry Mouth - Xerostomia is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Easily Angered or Annoyed - Irritability is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Fast Heartbeat - Tachyarrhythmia is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Fever is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Head Pain - Headache Disorder is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Incomplete or Infrequent Bowel Movements - Constipation is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Nervous - Nervousness is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Nightmares is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Over Excitement - Excitement is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Problems with Eyesight - Visual Changes is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Rash - Skin Rash is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Ringing in the Ears - Tinnitus is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Sun-Sensitive Skin - Skin Photosensitivity is a Frequently Occurring Side Effect of Zofran and Promethazine combined

Click for a searchable interactive map of all Side Effects associated with Zofran and Promethazine combined.

Zofran and Promethazine Drug-Drug Interactions

There are no drug-drug interactions between Zofran and Promethazine.

Zofran has 2 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Zofran.

Zofran Oral Contraindications
(grouped by decreasing seriousness level)

Relative Contraindications

Severe Hepatic Disease - Severe Liver Disease is a contraindication of Zofran.

Contraindication Warnings

Extrapyramidal Disease - Extrapyramidal Reaction is a contraindication of Zofran.

Promethazine has 22 Condition Contraindications

If you have any of these Conditions then you should carefully evaluate the risks of taking Promethazine.

Promethazine Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications

Coma is a contraindication of Promethazine.

Lactating Mother - A Mother who is Producing Milk and Breastfeeding is a contraindication of Promethazine.

Neuroleptic Malignant Syndrome is a contraindication of Promethazine.

Respiratory Depression - Significant Decrease in Lung Function is a contraindication of Promethazine.

Relative Contraindications

Benign Prostatic Hypertrophy - Enlarged Prostate is a contraindication of Promethazine.

Bladder Outflow Obstruction - Blockage of Urinary Bladder is a contraindication of Promethazine.

CNS Depression - Abnormal Nervous System Function Affecting Mental Alertness is a contraindication of Promethazine.

Chronic Idiopathic Constipation - Chronic Difficulty having a Bowel Movement is a contraindication of Promethazine.

Chronic Obstructive Pulmonary Disease - Chronic Obstructive Lung Disease is a contraindication of Promethazine.

Narrow Angle Glaucoma - Closed Angle Glaucoma is a contraindication of Promethazine.

Pyloroduodenal Obstruction - Narrowing of Opening Between Stomach and Small Intestine is a contraindication of Promethazine.

Sleep Apnea - Temporarily Stops Breathing While Sleeping is a contraindication of Promethazine.

Stenosing Peptic Ulcer is a contraindication of Promethazine.

Contraindication Warnings

Bone Marrow Depression - Decreased Function of Bone Marrow is a contraindication of Promethazine.

CNS Disorder - Diseases of the Brain and Spinal Cord is a contraindication of Promethazine.

Disease of Cardiovascular System - Disease of the Heart and Blood Vessels is a contraindication of Promethazine.

Disease of Liver - Liver Problems is a contraindication of Promethazine.

Encephalopathy - Any Disorder of the Brain is a contraindication of Promethazine.

Epilepsy - Epileptic Seizure is a contraindication of Promethazine.

Gastrointestinal Obstruction - Stomach or Intestine Blockage is a contraindication of Promethazine.

Hyperbilirubinemia - High Amount of Bilirubin in the Blood is a contraindication of Promethazine.

Lower Seizure Threshold is a contraindication of Promethazine.

Zofran - Symptoms of overdose may include
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

Promethazine - Symptoms of overdose may include
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include severe dizziness, fainting, very slow/shallow breathing, loss of consciousness, muscle stiffness/twitching, hot dry skin, widened pupils.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.