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Brief Intro
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Uses of Depakote
 
Depakote is also known by the generic name Divalproex


USES:
This medication is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.


Uses of Zyprexa
 
Zyprexa is also known by the generic name Olanzapine


USES:
This medication is used to treat certain mental/mood conditions (such as schizophrenia, bipolar mania). It may also be used in combination with other medication to treat depression. It works by helping to restore the balance of certain natural chemicals in the brain (neurotransmitters).

Some of the benefits of continued use of this medication include feeling less nervous, better concentration, and reduced episodes of hallucinations.

Talk to the doctor about the risks and benefits of treatment (especially when used in teenagers). See also Precautions section.


Depakote and Zyprexa Have 5 Life Threatening (Major) Side Effects in Common
 
Critical Seriousness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of both Depakote and Zyprexa.
Critical Seriousness - Decreased Blood Platelets - Thrombocytopenic Disorder is a Life Threatening Side Effect of both Depakote and Zyprexa.
Critical Seriousness - Fluid Retention in the Legs, Feet, Arms or Hands - Peripheral Edema is a Life Threatening Side Effect of both Depakote and Zyprexa.
Critical Seriousness - Mental Impairment is a Life Threatening Side Effect of both Depakote and Zyprexa.
Critical Seriousness - Puffy Face from Water Retention - Facial Edema is a Life Threatening Side Effect of both Depakote and Zyprexa.
Click for a searchable interactive map of all Life Threatening Side Effects associated with Depakote and Zyprexa.

Depakote Has 15 Life Threatening (Major) Side Effects Not Found in Zyprexa
 
Critical Seriousness - Problem Behavior - Behavioral Disorders is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Acute Inflammation of the Pancreas - Acute Pancreatitis is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Seeing Spots - Visual Disturbance of Seeing Spots is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Mood Changes is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Acute Liver Failure - Acute Hepatic Failure is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - High Amount of Ammonium in the Blood - Hyperammonemia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Double Vision - Diplopia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Involuntary Eye Movement - Nystagmus is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Hepatitis caused by Drugs - Drug-Induced Hepatitis is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Decrease in the Ability of Platelet Cells to Clot - Platelet Aggregation Inhibition is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Having Thoughts of Suicide - Suicidal Ideation is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Swollen Lymph Nodes - Lymphadenopathy is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Low Body Temperature - Hypothermia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Click for a searchable interactive map of all Life Threatening Side Effects associated with Depakote and Zyprexa.

Zyprexa Has 27 Life Threatening (Major) Side Effects Not Found in Depakote
 
Critical Seriousness - Diabetic Ketoacidosis - Diabetes Mellitus Ketoacidosis is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Parkinson Symptoms - Parkinsonism is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Diabetic Hyperosmolar Coma is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Decreased White Blood Cells - Leukopenia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Loss of Memory - Memory Impairment is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Diabetes - Diabetes Mellitus is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Decreased Neutrophils a Type of White Blood Cell - Neutropenic Disorder is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Sunstroke - Heat Stroke is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Disorder involving Personality Changes - Personality Disorders is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Extrapyramidal Reaction - Extrapyramidal Disease is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Seizures - Seizure Disorder is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - A Feeling of Restlessness with Inability to Sit Still - Akathisia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - High Blood Sugar - Hyperglycemia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - High Amount of Triglyceride in the Blood - Hypertriglyceridemia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Deficiency of Granulocytes a Type of White Blood Cell - Agranulocytosis is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Extreme Sense of Well Being - Euphoria is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Problems with Eyesight - Visual Changes is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Hepatitis is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Fever is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - High Amount of Fats in the Blood - Hyperlipidemia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Neuroleptic Malignant Syndrome is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Stroke - Cerebrovascular Accident is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Abnormal Movements of Face Muscles and Tongue - Tardive Dyskinesia is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Chest Pain is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Blocked Bowels with No Movement - Ileus is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Problem with Periods - Menstrual Disorder is a Life Threatening Side Effect of Depakote but not Zyprexa.
Critical Seriousness - Rash - Skin Rash is a Life Threatening Side Effect of Depakote but not Zyprexa.
Click for a searchable interactive map of all Life Threatening Side Effects associated with Depakote and Zyprexa.

Depakote and Zyprexa Have 4 Most Frequently Occurring Side Effects in Common
 
Dizzy - Dizziness is a Frequently Occurring Side Effect of both Depakote and Zyprexa.
Drowsiness - Drowsy is a Frequently Occurring Side Effect of both Depakote and Zyprexa.
Weight Gain is a Frequently Occurring Side Effect of both Depakote and Zyprexa.
Involuntary Quivering - Tremors is a Frequently Occurring Side Effect of both Depakote and Zyprexa.
Click for a searchable interactive map of all Side Effects associated with Depakote and Zyprexa.

Depakote Has 13 Most Frequently Occurring Side Effects Not Found in Zyprexa
 
Throat Irritation - Pharyngitis is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Infection is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Irregular Periods - Irregular Menstrual Periods is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Loss of Appetite - Anorexia is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Chronic Trouble Sleeping - Insomnia is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Throwing Up - Vomiting is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Ringing in the Ears - Tinnitus is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Hair Loss - Alopecia is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Diarrhea is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Indigestion - Dyspepsia is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Weight Loss is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Stomach Cramps - Abdominal Pain with Cramps is a Frequently Occurring Side Effect of Depakote but not Zyprexa.
Click for a searchable interactive map of all Side Effects associated with Depakote and Zyprexa.

Zyprexa Has 13 Most Frequently Occurring Side Effects Not Found in Zyprexa
 
Parkinson Symptoms - Parkinsonism is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Incomplete or Infrequent Bowel Movements - Constipation is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Backache - Back Pain is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Increased Hunger - Increased Appetite is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Head Pain - Headache Disorder is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Feeling Weak - General Weakness is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Disorder involving Personality Changes - Personality Disorders is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Blood Pressure Drop Upon Standing - Orthostatic Hypotension is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
A Feeling of Restlessness with Inability to Sit Still - Akathisia is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Increased Levels of Prolactin in the Blood - Hyperprolactinemia is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Lazy Eye - Amblyopia is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Inflammation of the Nose - Rhinitis is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Dry Mouth - Xerostomia is a Frequently Occurring Side Effect of Zyprexa but not Depakote.
Click for a searchable interactive map of all Side Effects associated with Depakote and Zyprexa.

Depakote and Zyprexa Treat 6 Conditions in Common
 
Bipolar Disorder in Remission is treated by both Depakote and Zyprexa.
Bipolar I Disorder with Most Recent Episode Mixed - Mixed Bipolar I Disorder is treated by both Depakote and Zyprexa.
Manic Phase of Manic-Depression - Manic Bipolar Disorder is treated by both Depakote and Zyprexa.

Depakote has 16 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Depakote.

Depakote Oral Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications 

Acute Pancreatitis - Acute Inflammation of the Pancreas is a contraindication of Depakote.

Carbamyl Phosphate Synthetase Deficiency - Inherited Deficiency of Carbamyl Phosphate Synthetase is a contraindication of Depakote.

Chronic Pancreatitis - Chronic Inflammation of the Pancreas is a contraindication of Depakote.

Disease of Liver - Liver Problems is a contraindication of Depakote.

Ornithine Carbamyltransferase Deficiency is a contraindication of Depakote.

Pregnancy is a contraindication of Depakote.

Relative Contraindications 

Hyperammonemia - High Amount of Ammonium in the Blood is a contraindication of Depakote.

Porphyria is a contraindication of Depakote.

Thrombocytopenic Disorder - Decreased Blood Platelets is a contraindication of Depakote.

Contraindication Warnings 

Blood Dyscrasias - Blood Disorder is a contraindication of Depakote.

Depression is a contraindication of Depakote.

Hypoalbuminemia - Low Amount of Albumin Proteins in the Blood is a contraindication of Depakote.

Organic Mental Disorder - Dysfunction of the Brain is a contraindication of Depakote.

Renal Disease - Kidney Disease is a contraindication of Depakote.

Suicidal Ideation - Having Thoughts of Suicide is a contraindication of Depakote.

Valproic Acid Toxicity - Poisoning by Drug Valproic Acid is a contraindication of Depakote.

Zyprexa has 40 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Zyprexa.

Zyprexa Oral Contraindications
(grouped by decreasing seriouosness level)

Absolute Contraindications 

Agranulocytosis - Deficiency of Granulocytes a Type of White Blood Cell is a contraindication of Zyprexa.

Neuroleptic Malignant Syndrome is a contraindication of Zyprexa.

Relative Contraindications 

Breast Carcinoma - Breast Cancer is a contraindication of Zyprexa.

Cerebrovascular Accident - Stroke is a contraindication of Zyprexa.

Cerebrovascular Disorder - Any Disorder of the Blood Vessels of the Brain is a contraindication of Zyprexa.

Conduction Disorder of the Heart - Abnormal Heart Rhythm is a contraindication of Zyprexa.

Dehydration - Extreme Loss of Body Water is a contraindication of Zyprexa.

Diabetes Mellitus - Diabetes is a contraindication of Zyprexa.

Esophageal Dysmotility - Problems with Food Passing Through the Esophagus is a contraindication of Zyprexa.

Heart Failure is a contraindication of Zyprexa.

Hypercholesterolemia - High Cholesterol is a contraindication of Zyprexa.

Hyperglycemia - High Blood Sugar is a contraindication of Zyprexa.

Hyperlipidemia - High Amount of Fats in the Blood is a contraindication of Zyprexa.

Hypertriglyceridemia - High Amount of Triglyceride in the Blood is a contraindication of Zyprexa.

Hypotension - Abnormally Low Blood Pressure is a contraindication of Zyprexa.

Hypovolemia - Decreased Blood Volume is a contraindication of Zyprexa.

Leukopenia - Decreased White Blood Cells is a contraindication of Zyprexa.

Lower Seizure Threshold is a contraindication of Zyprexa.

Metabolic Syndrome X is a contraindication of Zyprexa.

Myocardial Infarction - Heart Attack is a contraindication of Zyprexa.

Myocardial Ischemia - Disease of Inadequate Blood Flow to the Heart Muscle is a contraindication of Zyprexa.

Narrow Angle Glaucoma - Closed Angle Glaucoma is a contraindication of Zyprexa.

Neutropenic Disorder - Decreased Neutrophils a Type of White Blood Cell is a contraindication of Zyprexa.

Obesity - Overweight is a contraindication of Zyprexa.

Orthostatic Hypotension - Blood Pressure Drop Upon Standing is a contraindication of Zyprexa.

Paralytic Ileus - Paralysis of the Intestines is a contraindication of Zyprexa.

Predisposition to Aspiration - Susceptible to Breathing Fluid Into Lungs is a contraindication of Zyprexa.

Seizure Disorder - Seizures is a contraindication of Zyprexa.

Senile Dementia - Dementia in an Elderly Person is a contraindication of Zyprexa.

Severe Hepatic Disease - Severe Liver Disease is a contraindication of Zyprexa.

Suicidal Ideation - Having Thoughts of Suicide is a contraindication of Zyprexa.

Symptomatic Prostatic Hypertrophy - Enlarged Prostate with Urination Problems is a contraindication of Zyprexa.

Tardive Dyskinesia - Abnormal Movements of Face Muscles and Tongue is a contraindication of Zyprexa.

Transient Cerebral Ischemia - Transient Ischemic Attack is a contraindication of Zyprexa.

Contraindication Warnings 

Abnormal Hepatic Function Tests - Abnormal Liver Function Tests is a contraindication of Zyprexa.

Bradycardia - Slow Heartbeat is a contraindication of Zyprexa.

Hyperprolactinemia - Increased Levels of Prolactin in the Blood is a contraindication of Zyprexa.

Sinus Tachycardia is a contraindication of Zyprexa.

Tobacco Smoker - Tobacco Smoking is a contraindication of Zyprexa.

Weight Gain is a contraindication of Zyprexa.
Depakote - Symptoms of overdose may include
excessive drowsiness, coma, irregular/slowed/skipped heart beats (heart block).

Zyprexa - Symptoms of overdose may include
severe drowsiness, slurred speech, slowed breathing, or seizures.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

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