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Uses of Enbrel
 
Enbrel is also known by the generic name Etanercept


USES:
This medication is used alone or in combination with an immunosuppressant (such as methotrexate) to treat certain types of arthritis (such as rheumatoid, psoriatic, juvenile idiopathic, and ankylosing spondylitis), as well as a skin condition called psoriasis. These conditions are caused by an overactive immune system (autoimmune disease). The immune system attacks the body's own healthy cells, causing inflammation in the joints and skin.

Etanercept controls your body's defensive response by blocking the action of a certain natural substance (TNF) that is used by the immune system. Treatment decreases redness, itching and scaly patches in psoriasis as well as the pain, swelling and stiffness of joints in arthritis. This medication can stop the progression of disease and joint damage, resulting in improved daily functioning and quality of life.

This medication treats but does not cure autoimmune diseases. Symptoms usually return within 1 month of stopping the medication.


Uses of Orencia
 
Orencia is also known by the generic name Abatacept


USES:
This medication is used alone or with other medications (e.g., methotrexate) to treat rheumatoid arthritis, a condition in which the body's own defense system (immune system) attacks the healthy tissues around the joints. It is usually used when other medications for rheumatoid arthritis are not successful in controlling the disease. Abatacept helps slow joint damage and reduce the joint pain/swelling so you can move better. It works by weakening your immune system and decreasing swelling (inflammation).


Enbrel and Orencia Have 10 Life Threatening (Major) Side Effects in Common
 
Critical Seriousness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Pneumonia is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Infection is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Abnormally Low Blood Pressure - Hypotension is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Bronchitis is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - High Blood Pressure - Hypertension is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Acute Infection of the Nose, Throat or Sinus - Upper Respiratory Infection is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Hives - Urticaria is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Malignant Tumor or Cancer - Malignancy is a Life Threatening Side Effect of both Enbrel and Orencia.
Critical Seriousness - Bacterial Infection of the Kidney and Renal Pelvis - Pyelonephritis is a Life Threatening Side Effect of both Enbrel and Orencia.

Enbrel Has 38 Life Threatening (Major) Side Effects Not Found in Orencia
 
Critical Seriousness - Bacterial Infection of Blood or Tissues affecting the Whole Body - Bacterial Septicemia is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - A Fungal Infection - Aspergillosis - Aspergillosis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Acquired Decrease of All Cells in the Blood - Pancytopenia is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Low Blood Counts due to Bone Marrow Failure - Aplastic Anemia is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Anemia is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Stevens-Johnson Syndrome is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Reactivated Tuberculosis - Reactivation Tuberculosis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Decreased White Blood Cells - Leukopenia is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Bacteria causing an Infection in the Joints - Septic Arthritis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Chickenpox is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Infection caused by Blastomyces Dermatitidis Fungus - Blastomycosis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Decreased Blood Platelets - Thrombocytopenic Disorder is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Guillain-Barre Syndrome is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Acute Inflammation of the Pancreas - Acute Pancreatitis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Fluid Retention in the Legs, Feet, Arms or Hands - Peripheral Edema is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Malignant Lymphoma is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Drug Therapy that Worsens or Flares Psoriasis - Drug-Exacerbated Psoriasis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Active Tuberculosis - Acute Tuberculosis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Infection due to the Candida Fungus - Candidiasis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Infection caused by Coccidioides Fungus - Coccidioidomycosis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Type of Infection caused by Histoplasmosis Fungus - Histoplasmosis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Lupus-Like Syndrome is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Seizures - Seizure Disorder is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Infection caused by a Fungus - Fungal Infections is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Liver Inflammation caused by Body's Own Immune Response - Autoimmune Hepatitis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Toxic Epidermal Necrolysis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Worsening of Chronic Heart Failure is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Abscess Within the Abdomen - Intra-Abdominal Abscess is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Leukemia is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Inflamed Spinal Cord - Myelitis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Sudden Blindness and Pain Upon Moving the Eye - Optic Neuritis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Chronic Heart Failure is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Inflammation of the Lining of the Stomach and Intestines - Gastroenteritis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Multiple Sclerosis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Inflammation of the Gallbladder - Cholecystitis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Bleeding of the Stomach or Intestines - Gastrointestinal Hemorrhage is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Abscess is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Relapse of Hepatitis B Infection Symptoms - Reactivation Hepatitis B is a Life Threatening Side Effect of Enbrel but not Orencia.

Orencia Has 13 Life Threatening (Major) Side Effects Not Found in Enbrel
 
Critical Seriousness - The Flu - Influenza is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Diverticulitis - Diverticulitis of Gastrointestinal Tract is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Dizzy - Dizziness is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Shingles - Herpes Zoster is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Allergic Reaction caused by a Drug - Hypersensitivity Drug Reactions is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Foot Pain - Feet Pain is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Sinus Irritation and Congestion - Sinusitis is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Urinary Tract Infection - Urinary Tract Infections is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Rash - Skin Rash is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Wheezing is a Life Threatening Side Effect of Enbrel but not Orencia.
Critical Seriousness - Cellulitis is a Life Threatening Side Effect of Enbrel but not Orencia.

Enbrel and Orencia Have 5 Most Frequently Occurring Side Effects in Common
 
Throat Irritation - Pharyngitis is a Frequently Occurring Side Effect of both Enbrel and Orencia.
Head Pain - Headache Disorder is a Frequently Occurring Side Effect of both Enbrel and Orencia.
Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of both Enbrel and Orencia.
Infection is a Frequently Occurring Side Effect of both Enbrel and Orencia.
Acute Infection of the Nose, Throat or Sinus - Upper Respiratory Infection is a Frequently Occurring Side Effect of both Enbrel and Orencia.

Enbrel Has 6 Most Frequently Occurring Side Effects Not Found in Orencia
 
Chickenpox is a Frequently Occurring Side Effect of Enbrel but not Orencia.
Throwing Up - Vomiting is a Frequently Occurring Side Effect of Enbrel but not Orencia.
Signs and Symptoms at Injection Site - Injection Site Sequelae is a Frequently Occurring Side Effect of Enbrel but not Orencia.
Inflammation of the Nose - Rhinitis is a Frequently Occurring Side Effect of Enbrel but not Orencia.
Stomach Cramps - Abdominal Pain with Cramps is a Frequently Occurring Side Effect of Enbrel but not Orencia.
Sinus Irritation and Congestion - Sinusitis is a Frequently Occurring Side Effect of Enbrel but not Orencia.

Orencia Has 1 Most Frequently Occurring Side Effects Not Found in Orencia
 
High Blood Pressure - Hypertension is a Frequently Occurring Side Effect of Orencia but not Enbrel.

Enbrel and Orencia Treat 7 Conditions in Common
 
Rheumatoid Arthritis is treated by both Enbrel and Orencia.
Joint Inflammatory Disease in Children and Young Adults - Juvenile Rheumatoid Arthritis is treated by both Enbrel and Orencia.

Enbrel has 40 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Enbrel.

Enbrel Subcutaneous Contraindications
(grouped by decreasing seriousness level)

Absolute Contraindications 

Acute Decompensated Heart Failure - Suddenly Serious Symptoms of Heart Failure is a contraindication of Enbrel.

Acute Tuberculosis - Active Tuberculosis is a contraindication of Enbrel.

Aplastic Anemia - Low Blood Counts due to Bone Marrow Failure is a contraindication of Enbrel.

Aspergillosis - A Fungal Infection - Aspergillosis is a contraindication of Enbrel.

Autoimmune Hepatitis - Liver Inflammation caused by Body's Own Immune Response is a contraindication of Enbrel.

Blastomycosis - Infection caused by Blastomyces Dermatitidis Fungus is a contraindication of Enbrel.

Coccidioidomycosis - Infection caused by Coccidioides Fungus is a contraindication of Enbrel.

Demyelination - Demyelinating Disease is a contraindication of Enbrel.

Disseminated Candidiasis - Candidiasis Yeast Infection that Spreads Throughout Body is a contraindication of Enbrel.

Histoplasmosis - Type of Infection caused by Histoplasmosis Fungus is a contraindication of Enbrel.

Leukemia is a contraindication of Enbrel.

Lupus-Like Syndrome is a contraindication of Enbrel.

Malignancy - Malignant Tumor or Cancer is a contraindication of Enbrel.

Malignant Lymphoma is a contraindication of Enbrel.

Miliary Tuberculosis - Tuberculosis of Lungs which Spreads to Other Body Parts is a contraindication of Enbrel.

Opportunistic Fungal Infection - A Fungal Infection that Occurs Under Certain Circumstances is a contraindication of Enbrel.

Pneumocystis Carinii Pneumonia - Pneumonia caused by Pneumocystis Carinii is a contraindication of Enbrel.

Reactivation Hepatitis B - Relapse of Hepatitis B Infection Symptoms is a contraindication of Enbrel.

Reactivation Tuberculosis - Reactivated Tuberculosis is a contraindication of Enbrel.

Sepsis Syndrome is a contraindication of Enbrel.

Severe Infection is a contraindication of Enbrel.

Relative Contraindications 

Alcoholic Liver Damage - Hardening of the Liver caused by Alcohol is a contraindication of Enbrel.

Blood Dyscrasias - Blood Disorder is a contraindication of Enbrel.

Candidiasis - Infection due to the Candida Fungus is a contraindication of Enbrel.

Chronic Heart Failure is a contraindication of Enbrel.

Chronic Infection - Infection that Lasts a Long Time is a contraindication of Enbrel.

Chronic Type B Viral Hepatitis - Chronic Hepatitis B is a contraindication of Enbrel.

Hepatitis B Immune due to Latent Hepatitis B Infection - Resolved Hepatitis B is a contraindication of Enbrel.

Immunosuppression - Reduction in the Body's Resistance to Infection is a contraindication of Enbrel.

Inactive Tuberculosis is a contraindication of Enbrel.

Multiple Sclerosis is a contraindication of Enbrel.

Neutropenic Disorder - Decreased Neutrophils a Type of White Blood Cell is a contraindication of Enbrel.

Optic Neuritis - Sudden Blindness and Pain Upon Moving the Eye is a contraindication of Enbrel.

Pancytopenia - Acquired Decrease of All Cells in the Blood is a contraindication of Enbrel.

Seizure Disorder - Seizures is a contraindication of Enbrel.

Severe Diabetes Mellitus - Severe Form of Diabetes is a contraindication of Enbrel.

Uncontrolled Diabetes Mellitus - Diabetes that is Not Under Control is a contraindication of Enbrel.

Viral Hepatitis B - Hepatitis B is a contraindication of Enbrel.

Viral Infection - Infection caused by a Virus is a contraindication of Enbrel.

Contraindication Warnings 

Oral Cavity Disorders - Problem with Mouth, Teeth, Jaw or Pharynx is a contraindication of Enbrel.

Orencia has 6 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Orencia.

Orencia Intravenous Contraindications
(grouped by decreasing seriouosness level)

Absolute Contraindications 

Lactating Mother - A Mother who is Producing Milk and Breastfeeding is a contraindication of Orencia.

Relative Contraindications 

Inactive Tuberculosis is a contraindication of Orencia.

Severe Infection is a contraindication of Orencia.

Contraindication Warnings 

Chronic Obstructive Pulmonary Disease - Chronic Obstructive Lung Disease is a contraindication of Orencia.

Immunosuppression - Reduction in the Body's Resistance to Infection is a contraindication of Orencia.

Malignancy - Malignant Tumor or Cancer is a contraindication of Orencia.
Enbrel - Symptoms of overdose may include
If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canada residents should call their local poison control center directly.

Orencia - Symptoms of overdose may include
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

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