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Drug Interactions and Side Effects of Methadone

Methadone has 54 Side Effects total
27 are Life Threatening
9 Occur Most Frequently

Uses of Methadone
 
USES:
This medication is used to treat moderate to severe pain. Methadone belongs to a class of drugs known as narcotic (opiate) analgesics. It works in the brain to change how your body feels and responds to pain.

This medication is also used to treat addiction to narcotic drugs (such as heroin) as part of an approved treatment program. It helps prevent withdrawal symptoms caused by stopping other narcotic drugs.


Methadone has 27 Life Threatening (Critical) Side Effects
 
Critical Seriousness - A Spasm of the Larynx - Laryngismus is a Life Threatening Side Effect of Methadone
Critical Seriousness - Abnormal Heart Rhythm - Conduction Disorder of the Heart is a Life Threatening Side Effect of Methadone
Critical Seriousness - Bronchospasm - Bronchospastic Pulmonary Disease is a Life Threatening Side Effect of Methadone
Critical Seriousness - Change in Pulse - Pulse Changes is a Life Threatening Side Effect of Methadone
Critical Seriousness - Collapsed Portion of Lung - Atelectasis is a Life Threatening Side Effect of Methadone
Critical Seriousness - Complete Stoppage of the Heart - Cardiac Arrest is a Life Threatening Side Effect of Methadone
Critical Seriousness - Confused - Impaired Cognition is a Life Threatening Side Effect of Methadone
Critical Seriousness - Depression is a Life Threatening Side Effect of Methadone
Critical Seriousness - Fast Heartbeat - Tachyarrhythmia is a Life Threatening Side Effect of Methadone
Critical Seriousness - Fluid in the Lungs - Pulmonary Edema is a Life Threatening Side Effect of Methadone
Critical Seriousness - Giant Hives - Angioedema is a Life Threatening Side Effect of Methadone
Critical Seriousness - Hallucination - Hallucinations is a Life Threatening Side Effect of Methadone
Critical Seriousness - Hives - Urticaria is a Life Threatening Side Effect of Methadone
Critical Seriousness - Increased Spinal Fluid Pressure - Increased Cerebrospinal Fluid Pressure is a Life Threatening Side Effect of Methadone
Critical Seriousness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Methadone
Critical Seriousness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Methadone
Critical Seriousness - Lung Failure causing Loss of Breath - Respiratory Insufficiency is a Life Threatening Side Effect of Methadone
Critical Seriousness - Prolonged Q-T Interval on EKG - Prolonged QT Interval is a Life Threatening Side Effect of Methadone
Critical Seriousness - Rash - Skin Rash is a Life Threatening Side Effect of Methadone
Critical Seriousness - Reaction due to an Allergy - Allergic Reactions is a Life Threatening Side Effect of Methadone
Critical Seriousness - Seizures - Seizure Disorder is a Life Threatening Side Effect of Methadone
Critical Seriousness - Shock is a Life Threatening Side Effect of Methadone
Critical Seriousness - Significant Decrease in Lung Function - Respiratory Depression is a Life Threatening Side Effect of Methadone
Critical Seriousness - Slow Heartbeat - Bradycardia is a Life Threatening Side Effect of Methadone
Critical Seriousness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Methadone
Critical Seriousness - Very Rapid Heartbeat - Torsades de Pointes - Torsades de Pointes is a Life Threatening Side Effect of Methadone
Critical Seriousness - Vocal Cord Swelling - Laryngeal Edema is a Life Threatening Side Effect of Methadone

Methadone has 9 Most Frequently Occurring Side Effects
 
Abnormally Low Blood Pressure - Hypotension is a Frequently Occurring Side Effect of Methadone
Dizzy - Dizziness is a Frequently Occurring Side Effect of Methadone
Drowsiness - Drowsy is a Frequently Occurring Side Effect of Methadone
Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Methadone
Feeling Faint - Fainting is a Frequently Occurring Side Effect of Methadone
Feeling Weak - General Weakness is a Frequently Occurring Side Effect of Methadone
Incomplete or Infrequent Bowel Movements - Constipation is a Frequently Occurring Side Effect of Methadone
Not Feeling Well - Malaise is a Frequently Occurring Side Effect of Methadone
Throwing Up - Vomiting is a Frequently Occurring Side Effect of Methadone

Methadone Drug-Drug Interactions
 
Methadone has interactions of severe seriousness with 61 drug(s):
Methadone has 1 severe interactions with Amiodarone. Click here to see them
Methadone has 1 severe interactions with Amiodarone Hcl In D5w. Click here to see them
Methadone has 1 severe interactions with Artemether-Lumefantrine. Click here to see them
Methadone has 1 severe interactions with Atapryl. Click here to see them
Methadone has 1 severe interactions with Azilect. Click here to see them
Methadone has 1 severe interactions with Bepridil. Click here to see them
Methadone has 1 severe interactions with Carbex. Click here to see them
Methadone has 1 severe interactions with Cisapride. Click here to see them
Methadone has 1 severe interactions with Coartem. Click here to see them
Methadone has 1 severe interactions with Cordarone. Click here to see them
Methadone has 1 severe interactions with Cordarone Iv. Click here to see them
Methadone has 1 severe interactions with Depade. Click here to see them
Methadone has 1 severe interactions with Didanosine. Click here to see them
Methadone has 1 severe interactions with Disopyramide. Click here to see them
Methadone has 1 severe interactions with Dronedarone. Click here to see them
Methadone has 2 severe interactions with Droperidol. Click here to see them
Methadone has 1 severe interactions with Eldepryl. Click here to see them
Methadone has 1 severe interactions with Emsam. Click here to see them
Methadone has 1 severe interactions with Fareston. Click here to see them
Methadone has 1 severe interactions with Fentanyl-Droperidol. Click here to see them
Methadone has 1 severe interactions with Furazolidone. Click here to see them
Methadone has 1 severe interactions with Furoxone. Click here to see them
Methadone has 1 severe interactions with Halfan. Click here to see them
Methadone has 1 severe interactions with Halofantrine. Click here to see them
Methadone has 1 severe interactions with Inapsine. Click here to see them
Methadone has 1 severe interactions with Innovar. Click here to see them
Methadone has 1 severe interactions with Isocarboxazid. Click here to see them
Methadone has 1 severe interactions with Levomethadyl. Click here to see them
Methadone has 1 severe interactions with Linezolid. Click here to see them
Methadone has 1 severe interactions with Marplan. Click here to see them
Methadone has 1 severe interactions with Matulane. Click here to see them
Methadone has 1 severe interactions with Methylene Blue (Antidote). Click here to see them
Methadone has 1 severe interactions with Multaq. Click here to see them
Methadone has 1 severe interactions with Naltrexone. Click here to see them
Methadone has 1 severe interactions with Naltrexone Microspheres. Click here to see them
Methadone has 1 severe interactions with Nardil. Click here to see them
Methadone has 1 severe interactions with Norpace. Click here to see them
Methadone has 1 severe interactions with Norpace Cr. Click here to see them
Methadone has 1 severe interactions with Orap. Click here to see them
Methadone has 1 severe interactions with Orlaam. Click here to see them
Methadone has 1 severe interactions with Pacerone. Click here to see them
Methadone has 1 severe interactions with Parnate. Click here to see them
Methadone has 1 severe interactions with Phenelzine. Click here to see them
Methadone has 1 severe interactions with Pimozide. Click here to see them
Methadone has 1 severe interactions with Procarbazine. Click here to see them
Methadone has 1 severe interactions with Propulsid. Click here to see them
Methadone has 1 severe interactions with Rasagiline. Click here to see them
Methadone has 1 severe interactions with Revia. Click here to see them
Methadone has 1 severe interactions with Selegiline. Click here to see them
Methadone has 1 severe interactions with Selegiline Hcl. Click here to see them
Methadone has 1 severe interactions with Sparfloxacin. Click here to see them
Methadone has 1 severe interactions with Toremifene. Click here to see them
Methadone has 1 severe interactions with Tranylcypromine. Click here to see them
Methadone has 1 severe interactions with Trexan. Click here to see them
Methadone has 1 severe interactions with Vascor. Click here to see them
Methadone has 1 severe interactions with Videx 2 Gram Pediatric. Click here to see them
Methadone has 1 severe interactions with Videx 4 Gram Pediatric. Click here to see them
Methadone has 1 severe interactions with Vivitrol. Click here to see them
Methadone has 1 severe interactions with Zagam. Click here to see them
Methadone has 1 severe interactions with Zelapar. Click here to see them
Methadone has 1 severe interactions with Zyvox. Click here to see them

Methadone has interactions of serious seriousness with 59 drug(s).

Methadone has interactions of moderate seriousness with 456 drug(s).

Methadone has interactions of unknown seriousness with 33 drug(s).

Methadone has 27 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Methadone.

Methadone Oral Contraindications
(grouped by decreasing seriouosness level)

Absolute Contraindications 

Hypercapnia - Excess Amount of Carbon Dioxide in the Blood is a contraindication of Methadone.

Paralytic Ileus - Paralysis of the Intestines is a contraindication of Methadone.

Pseudomembranous Enterocolitis - Severe Bloody Diarrhea from Antibiotics is a contraindication of Methadone.

Respiratory Depression - Significant Decrease in Lung Function is a contraindication of Methadone.

Torsades de Pointes - Very Rapid Heartbeat - Torsades de Pointes is a contraindication of Methadone.

Toxin-Mediated Diarrhea - Toxin from Microorganisms causing Diarrhea is a contraindication of Methadone.

Relative Contraindications 

Acute Asthma Attack - Asthma Attack is a contraindication of Methadone.

Bradycardia - Slow Heartbeat is a contraindication of Methadone.

Chronic Disease of Respiratory System - Chronic Lung or Breathing Passage Problem is a contraindication of Methadone.

Congenital Long QT Syndrome - Abnormal EKG with QT changes from Birth is a contraindication of Methadone.

Inflammatory Bowel Disease is a contraindication of Methadone.

Prolonged QT Interval - Prolonged Q-T Interval on EKG is a contraindication of Methadone.

Contraindication Warnings 

Acute Abdominal Pain - Intense Abdominal Pain is a contraindication of Methadone.

Benign Prostatic Hypertrophy - Enlarged Prostate is a contraindication of Methadone.

Conduction Disorder of the Heart - Abnormal Heart Rhythm is a contraindication of Methadone.

Disease of Liver - Liver Problems is a contraindication of Methadone.

Epilepsy - Epileptic Seizure is a contraindication of Methadone.

Gallbladder Disease - Disease of the Gallbladder is a contraindication of Methadone.

Head Injury is a contraindication of Methadone.

Hypotension - Abnormally Low Blood Pressure is a contraindication of Methadone.

Hypothyroidism - Underactive Thyroid is a contraindication of Methadone.

Intracranial Hypertension - High Pressure Within the Skull is a contraindication of Methadone.

Mood Changes is a contraindication of Methadone.

Procedure on Urinary System - Urinary Tract Surgery is a contraindication of Methadone.

Renal Disease - Kidney Disease is a contraindication of Methadone.

Substance Abuse - Misuse or Excessive Use of Drugs is a contraindication of Methadone.

Urethral Stricture - Narrowing of the Tube that Empties Urine From the Bladder is a contraindication of Methadone.

Methadone has 14 related brands and strengths:
 
Diskets 40 Mg Soluble Tab

Dolophine 10 Mg Tab

Dolophine 5 Mg Tab

Methadone 10 Mg Tab

Methadone 10 Mg/5 Ml Oral Soln

Methadone 10 Mg/Ml Injection

Methadone 10 Mg/Ml Oral Concentrate

Methadone 40 Mg Soluble Tab

Methadone 5 Mg Tab

Methadone 5 Mg/5 Ml Oral Soln

Methadone Intensol 10 Mg/Ml Oral Concentrate

Methadose 10 Mg Tab

Methadose 10 Mg/Ml Oral Concentrate

Methadose 40 Mg Soluble Tab

Methadone - Symptoms of overdose may include
slow/shallow breathing, slow heartbeat, loss of consciousness.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

IMPORTANT NOTICE: The drug information contained in this application is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not exhaustive and is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express terms of use. By continuing to view the drug information on this site, you agree to abide by such terms of use.
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