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Drug Interactions and Side Effects of Naproxen

Naproxen has 133 Side Effects total
102 are Life Threatening
12 Occur Most Frequently

Uses of Naproxen
 
USES:
Naproxen is used to relieve mild to moderate pain from various conditions. It reduces pain, swelling, and joint stiffness caused by arthritis. Reducing these symptoms helps you do more of your normal daily activities. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).

Enteric-coated tablets of naproxen are absorbed more slowly into your bloodstream than other forms of naproxen. Therefore, they should not be taken to relieve sudden pain (e.g., from gout attacks, menstrual pain, tendonitis, bursitis). Ask your doctor or pharmacist about other medications that can quickly relieve sudden pain from these conditions.


Naproxen has 102 Life Threatening (Critical) Side Effects
 
Critical Seriousness - A Rupture in the Wall of the Stomach or Intestine - Gastrointestinal Perforation is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Abnormal Heart Rhythm - Conduction Disorder of the Heart is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Abnormally Low Blood Pressure - Hypotension is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Acquired Decrease of All Cells in the Blood - Pancytopenia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Acute Inflammation of the Pancreas - Acute Pancreatitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Anemia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Anxious - Anxiety is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Bacterial Infection of Blood or Tissues affecting the Whole Body - Bacterial Septicemia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Bleeding Not Related to Menstrual Period - Metrorrhagia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Bleeding of the Stomach or Intestines - Gastrointestinal Hemorrhage is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Blood Clot - Thrombotic Disorder is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Bloody Urine - Hematuria is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Blurred Vision is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Bronchospasm - Bronchospastic Pulmonary Disease is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Bruise - Bruising is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Canker Sore - Aphthous Stomatitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Chest Tightness is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Chronic Heart Failure is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Coma is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Confused - Impaired Cognition is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Corneal Scar - Corneal Opacity is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Cramps is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Decreased Blood Platelets - Thrombocytopenic Disorder is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Decreased Neutrophils a Type of White Blood Cell - Neutropenic Disorder is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Decreased White Blood Cells - Leukopenia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Deficiency of Granulocytes a Type of White Blood Cell - Agranulocytosis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Depression is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Disease of the Heart and Blood Vessels - Disease of Cardiovascular System is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Double Vision - Diplopia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Elevation of Proteins in the Urine - Proteinuria is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Erythema Multiforme is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Excess Urination - Polyuria is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Excessive Thirst - Polydipsia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Fast Heartbeat - Tachyarrhythmia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Feeling Faint - Fainting is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Fever is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Fit - Tonic Clonic Seizure is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Fluid in the Lungs - Pulmonary Edema is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Giant Hives - Angioedema is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Glomerulonephritis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Hallucination - Hallucinations is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Hearing Problem - Hearing Disorder is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Heart Attack - Myocardial Infarction is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Hemolytic Anemia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Hemorrhage of Blood Under the Skin - Ecchymosis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Hepatitis caused by Drugs - Drug-Induced Hepatitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Hepatitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - High Amount of Potassium in the Blood - Hyperkalemia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - High Blood Pressure - Hypertension is a Life Threatening Side Effect of Naproxen
Critical Seriousness - High Blood Sugar - Hyperglycemia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Hives - Urticaria is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Increased Eosinophils in the Blood - Eosinophilia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Infiltration of White Blood Cells into the Lungs - Loeffler Syndrome is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Inflammation of the Bladder - Cystitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Inflammation of the Large Intestine - Colitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Interstitial Nephritis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Kidney Damage - Nephrotoxicity is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Kidney Disease - Renal Disease is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Kidney Failure - Renal Failure is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Large Purple or Brown Skin Blotches - Purpura is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Low Blood Counts due to Bone Marrow Failure - Aplastic Anemia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Low Blood Sugar - Hypoglycemic Disorder is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Lupus-Like Syndrome is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Meningitis Not Caused by an Infection - Non-Infective Meningitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Mental Impairment is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Mood Changes is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Muscle Pain - Myalgia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Nephrotic Syndrome is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Numbness, Tingling or Pain of Hands or Feet - Peripheral Neuropathy is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Pneumonia with High Amount of Eosinophil White Blood Cells - Eosinophilic Pneumonia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Pneumonia is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Problems with Eyesight - Visual Changes is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Rash - Skin Rash is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Reaction due to an Allergy - Allergic Reactions is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Red Blood in Bowel Movement - Bloody Stools is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Renal Papillary Necrosis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Renal Tubular Necrosis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Ringing in the Ears - Tinnitus is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Seizures - Seizure Disorder is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Significant Decrease in Lung Function - Respiratory Depression is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Skin Rash with Sloughing - Exfoliative Dermatitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Stevens-Johnson Syndrome is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Stomach Ulcer - Gastric Ulcer is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Stomach or Intestinal Ulcer - Gastrointestinal Ulcer is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Stroke - Cerebrovascular Accident is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Sudden Blindness and Pain Upon Moving the Eye - Optic Neuritis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Swollen Lymph Nodes - Lymphadenopathy is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Throwing Up Blood - Bloody Vomit is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Toxic Epidermal Necrolysis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Ulcer from Stomach Acid - Peptic Ulcer is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Ulcers of Esophagus - Esophageal Ulcer is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Vasculitis is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Visible Water Retention - Edema is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Vocal Cord Swelling - Laryngeal Edema is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Water Retention - Body Fluid Retention is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Wheezing is a Life Threatening Side Effect of Naproxen
Critical Seriousness - Yellowing of Skin or Eyes from Liver Problems - Jaundice is a Life Threatening Side Effect of Naproxen

Naproxen has 12 Most Frequently Occurring Side Effects
 
Dizzy - Dizziness is a Frequently Occurring Side Effect of Naproxen
Drowsiness - Drowsy is a Frequently Occurring Side Effect of Naproxen
Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Naproxen
Head Pain - Headache Disorder is a Frequently Occurring Side Effect of Naproxen
Heartburn is a Frequently Occurring Side Effect of Naproxen
Hives - Urticaria is a Frequently Occurring Side Effect of Naproxen
Incomplete or Infrequent Bowel Movements - Constipation is a Frequently Occurring Side Effect of Naproxen
Rash - Skin Rash is a Frequently Occurring Side Effect of Naproxen
Ringing in the Ears - Tinnitus is a Frequently Occurring Side Effect of Naproxen
Stomach Cramps - Abdominal Pain with Cramps is a Frequently Occurring Side Effect of Naproxen
Visible Water Retention - Edema is a Frequently Occurring Side Effect of Naproxen
Water Retention - Body Fluid Retention is a Frequently Occurring Side Effect of Naproxen

Naproxen Drug-Drug Interactions
 
Naproxen has interactions of severe seriousness with 4 drug(s):
Naproxen has 1 severe interactions with Cidofovir. Click here to see them
Naproxen has 3 severe interactions with Ketorolac. Click here to see them
Naproxen has 3 severe interactions with Toradol. Click here to see them
Naproxen has 1 severe interactions with Vistide. Click here to see them

Naproxen has interactions of serious seriousness with 42 drug(s).

Naproxen has interactions of moderate seriousness with 337 drug(s).

Naproxen has interactions of unknown seriousness with 0 drug(s).

Naproxen has 24 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Naproxen.

Naproxen Oral Contraindications
(grouped by decreasing seriouosness level)

Absolute Contraindications 

Post-operative from CABG Surgery - Time Immediately after Coronary Bypass Surgery is a contraindication of Naproxen.

Pregnancy is a contraindication of Naproxen.

Relative Contraindications 

Alcoholism - Habit of Drinking Too Much Alcohol is a contraindication of Naproxen.

Anemia is a contraindication of Naproxen.

Body Fluid Retention - Water Retention is a contraindication of Naproxen.

Cerebrovascular Accident - Stroke is a contraindication of Naproxen.

Chronic Heart Failure is a contraindication of Naproxen.

Disease of Cardiovascular System - Disease of the Heart and Blood Vessels is a contraindication of Naproxen.

Disease of Liver - Liver Problems is a contraindication of Naproxen.

Edema - Visible Water Retention is a contraindication of Naproxen.

Esophageal Dysmotility - Problems with Food Passing Through the Esophagus is a contraindication of Naproxen.

Gastrointestinal Hemorrhage - Bleeding of the Stomach or Intestines is a contraindication of Naproxen.

Gastrointestinal Perforation - A Rupture in the Wall of the Stomach or Intestine is a contraindication of Naproxen.

Gastrointestinal Ulcer - Stomach or Intestinal Ulcer is a contraindication of Naproxen.

Hypertension - High Blood Pressure is a contraindication of Naproxen.

Hypovolemia - Decreased Blood Volume is a contraindication of Naproxen.

Increased Cardiovascular Event Risk is a contraindication of Naproxen.

Myocardial Infarction - Heart Attack is a contraindication of Naproxen.

Renal Disease - Kidney Disease is a contraindication of Naproxen.

Thromboembolic Disorder - Obstruction of a Blood Vessel by a Blood Clot is a contraindication of Naproxen.

Tobacco Smoker - Tobacco Smoking is a contraindication of Naproxen.

Contraindication Warnings 

Abnormal Hepatic Function Tests - Abnormal Liver Function Tests is a contraindication of Naproxen.

Anemia is a contraindication of Naproxen.

Blood Coagulation Disorder - Blood Clotting Disorder is a contraindication of Naproxen.

Naproxen has 13 related brands and strengths:
 
Ec-Naprosyn 375 Mg Tab

Ec-Naprosyn 500 Mg Tab

Naprosyn 125 Mg/5 Ml Oral Susp

Naprosyn 250 Mg Tab

Naprosyn 375 Mg Tab

Naprosyn 500 Mg Tab

Naproxen 125 Mg/5 Ml Oral Susp

Naproxen 250 Mg Tab

Naproxen 375 Mg Tab

Naproxen 375 Mg Tab, Delayed Release

Naproxen 500 Mg Tab

Naproxen 500 Mg Tab, Delayed Release

Naproxen Powder

Naproxen - Symptoms of overdose may include
severe stomach pain, vomit that looks like coffee grounds, extreme drowsiness, slow or shallow breathing, seizures.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

IMPORTANT NOTICE: The drug information contained in this application is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not exhaustive and is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express terms of use. By continuing to view the drug information on this site, you agree to abide by such terms of use.
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