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Drug Interactions and Side Effects of Prempro

Prempro has 91 Side Effects total
51 are Life Threatening
21 Occur Most Frequently

Uses of Prempro
 
Prempro is also known by the generic name Conj Estrog-Medroxyprogest Ace


USES:
This medication is used to reduce menopause symptoms. It helps reduce episodes of flushing and sweating of the upper body and face, commonly called hot flashes. It also helps treat dryness, itching, and burning around the vagina. These symptoms occur when a woman's body no longer makes the usual amount of female hormone (estrogen). This medication is a combination of 2 types of female hormones:
estrogen (conjugated estrogens) and a progestin (medroxyprogesterone). A progestin is added to estrogen replacement therapy to reduce the risk of cancer of the uterus. A woman who has had her uterus removed does not need progestin and should not be treated with this combination medication.

If you need treatment only for vaginal menopause symptoms, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.

This medication may also be used to prevent bone loss (osteoporosis) in people at high risk who cannot take other drugs that are safe and effective to prevent or treat bone loss (e.g., raloxifene, bisphosphonates such as alendronate). These medicines should be considered for use before estrogen/progestin HRT therapy for osteoporosis.


Prempro has 51 Life Threatening (Critical) Side Effects
 
Critical Seriousness - A Blood Clot within the Blood Vessels of the Eye - Retinal Thrombosis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Abnormal Liver Function Tests - Abnormal Hepatic Function Tests is a Life Threatening Side Effect of Prempro
Critical Seriousness - Abnormally Long or Heavy Periods - Menorrhagia is a Life Threatening Side Effect of Prempro
Critical Seriousness - Abnormally Low Blood Pressure - Hypotension is a Life Threatening Side Effect of Prempro
Critical Seriousness - Absence of Menstrual Periods - Amenorrhea is a Life Threatening Side Effect of Prempro
Critical Seriousness - Acute Infection of the Nose, Throat or Sinus - Upper Respiratory Infection is a Life Threatening Side Effect of Prempro
Critical Seriousness - Acute Inflammation of the Pancreas - Acute Pancreatitis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Backache - Back Pain is a Life Threatening Side Effect of Prempro
Critical Seriousness - Bleeding Not Related to Menstrual Period - Metrorrhagia is a Life Threatening Side Effect of Prempro
Critical Seriousness - Blockage of Gallbladder - Gallbladder Obstruction is a Life Threatening Side Effect of Prempro
Critical Seriousness - Blood Clot Formation in Veins - Venous Thrombosis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Blood Clot in Lung - Pulmonary Thromboembolism is a Life Threatening Side Effect of Prempro
Critical Seriousness - Blood Clot in Vein - Thrombophlebitis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Breast Tenderness - Mastalgia is a Life Threatening Side Effect of Prempro
Critical Seriousness - Breast Tumor - Breast Neoplasm is a Life Threatening Side Effect of Prempro
Critical Seriousness - Bronchitis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Cancer in the Lining of the Uterus - Endometrial Carcinoma is a Life Threatening Side Effect of Prempro
Critical Seriousness - Cancer of the Ovary - Ovarian Carcinoma is a Life Threatening Side Effect of Prempro
Critical Seriousness - Chest Pain is a Life Threatening Side Effect of Prempro
Critical Seriousness - Depression is a Life Threatening Side Effect of Prempro
Critical Seriousness - Discharge of Milk in Men or Women when Not Breastfeeding - Galactorrhea not associated with Childbirth is a Life Threatening Side Effect of Prempro
Critical Seriousness - Disorder of Mental Processes due to a Brain Disease - Dementia is a Life Threatening Side Effect of Prempro
Critical Seriousness - Enlarged Breasts in Males - Gynecomastia is a Life Threatening Side Effect of Prempro
Critical Seriousness - Erythema Multiforme is a Life Threatening Side Effect of Prempro
Critical Seriousness - Fluid Retention in the Legs, Feet, Arms or Hands - Peripheral Edema is a Life Threatening Side Effect of Prempro
Critical Seriousness - Fluid Secretion from the Breast - Nipple Discharge is a Life Threatening Side Effect of Prempro
Critical Seriousness - Giant Hives - Angioedema is a Life Threatening Side Effect of Prempro
Critical Seriousness - Heart Attack - Myocardial Infarction is a Life Threatening Side Effect of Prempro
Critical Seriousness - Hepatitis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Hives - Urticaria is a Life Threatening Side Effect of Prempro
Critical Seriousness - Inflammation of the Bladder - Cystitis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Inflammation of the Lining of the Stomach and Intestines - Gastroenteritis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Insufficient Blood Supply to the Colon - Ischemic Colitis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Involuntary Muscle Movements - Involuntary Muscle Movement is a Life Threatening Side Effect of Prempro
Critical Seriousness - Irregular Periods - Irregular Menstrual Periods is a Life Threatening Side Effect of Prempro
Critical Seriousness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Prempro
Critical Seriousness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Lower Seizure Threshold is a Life Threatening Side Effect of Prempro
Critical Seriousness - Lump in the Breast - Lumps in Breasts is a Life Threatening Side Effect of Prempro
Critical Seriousness - Obstruction of a Blood Vessel by a Blood Clot - Thromboembolic Disorder is a Life Threatening Side Effect of Prempro
Critical Seriousness - Overgrowth of the Uterine Lining - Endometrial Hyperplasia is a Life Threatening Side Effect of Prempro
Critical Seriousness - Pancreatitis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Rash - Skin Rash is a Life Threatening Side Effect of Prempro
Critical Seriousness - Skin Condition Marked by Red and Painful Nodules - Erythema Nodosum is a Life Threatening Side Effect of Prempro
Critical Seriousness - Stroke - Cerebrovascular Accident is a Life Threatening Side Effect of Prempro
Critical Seriousness - Sudden Blindness and Pain Upon Moving the Eye - Optic Neuritis is a Life Threatening Side Effect of Prempro
Critical Seriousness - Swelling of the Abdomen - Abdominal Swelling is a Life Threatening Side Effect of Prempro
Critical Seriousness - The Flu - Influenza is a Life Threatening Side Effect of Prempro
Critical Seriousness - Uterine Fibroids is a Life Threatening Side Effect of Prempro
Critical Seriousness - Weight Gain is a Life Threatening Side Effect of Prempro
Critical Seriousness - Worsening of Asthma - Asthma Exacerbation is a Life Threatening Side Effect of Prempro

Prempro has 21 Most Frequently Occurring Side Effects
 
Bleeding Not Related to Menstrual Period - Metrorrhagia is a Frequently Occurring Side Effect of Prempro
Breast Tenderness - Mastalgia is a Frequently Occurring Side Effect of Prempro
Change in Appetite - Appetite Changes is a Frequently Occurring Side Effect of Prempro
Dizzy - Dizziness is a Frequently Occurring Side Effect of Prempro
Enlarged Breasts in Males - Gynecomastia is a Frequently Occurring Side Effect of Prempro
Feel Like Throwing Up - Nausea is a Frequently Occurring Side Effect of Prempro
Fluid Retention in the Legs, Feet, Arms or Hands - Peripheral Edema is a Frequently Occurring Side Effect of Prempro
Head Pain - Headache Disorder is a Frequently Occurring Side Effect of Prempro
Inflammation or Infection of Vagina - Vaginitis is a Frequently Occurring Side Effect of Prempro
Irregular Periods - Irregular Menstrual Periods is a Frequently Occurring Side Effect of Prempro
Loss of Appetite - Anorexia is a Frequently Occurring Side Effect of Prempro
Low Energy - Fatigue is a Frequently Occurring Side Effect of Prempro
Muscle Pain - Myalgia is a Frequently Occurring Side Effect of Prempro
Sinus Irritation and Congestion - Sinusitis is a Frequently Occurring Side Effect of Prempro
Stomach Cramps - Abdominal Pain with Cramps is a Frequently Occurring Side Effect of Prempro
Swelling of the Abdomen - Abdominal Swelling is a Frequently Occurring Side Effect of Prempro
Swelling of the Abdomen - Abdominal Swelling is a Frequently Occurring Side Effect of Prempro
Visible Water Retention - Edema is a Frequently Occurring Side Effect of Prempro
Weight Gain is a Frequently Occurring Side Effect of Prempro
Weight Gain is a Frequently Occurring Side Effect of Prempro
Weight Loss is a Frequently Occurring Side Effect of Prempro

Prempro Drug-Drug Interactions
 
Prempro has interactions of severe seriousness with 7 drug(s):
Prempro has 1 severe interactions with Anastrozole. Click here to see them
Prempro has 1 severe interactions with Arimidex. Click here to see them
Prempro has 1 severe interactions with Arimidex 30-Day Pack. Click here to see them
Prempro has 1 severe interactions with Aromasin. Click here to see them
Prempro has 1 severe interactions with Exemestane. Click here to see them
Prempro has 1 severe interactions with Femara. Click here to see them
Prempro has 1 severe interactions with Letrozole. Click here to see them

Prempro has interactions of serious seriousness with 39 drug(s).

Prempro has interactions of moderate seriousness with 754 drug(s).

Prempro has interactions of unknown seriousness with 0 drug(s).

Prempro has 58 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Prempro.

Prempro Oral Contraindications
(grouped by decreasing seriouosness level)

Absolute Contraindications 

Breast Carcinoma - Breast Cancer is a contraindication of Prempro.

Cerebrovascular Accident - Stroke is a contraindication of Prempro.

Cerebrovascular Disorder - Any Disorder of the Blood Vessels of the Brain is a contraindication of Prempro.

Deep Venous Thrombosis - Blood Clot in a Deep Vein is a contraindication of Prempro.

Disease of Liver - Liver Problems is a contraindication of Prempro.

Estrogen-Dependent Neoplasm - Tumor that is Dependent on Estrogen for Growth is a contraindication of Prempro.

Hypercoagulability States - Abnormal Increase in Ability of Blood to Clot is a contraindication of Prempro.

Metrorrhagia - Bleeding Not Related to Menstrual Period is a contraindication of Prempro.

Myocardial Infarction - Heart Attack is a contraindication of Prempro.

Pregnancy is a contraindication of Prempro.

Pulmonary Thromboembolism - Blood Clot in Lung is a contraindication of Prempro.

Severe Hepatic Disease - Severe Liver Disease is a contraindication of Prempro.

Severe Uncontrolled Hypertension - Severe Uncontrolled High Blood Pressure is a contraindication of Prempro.

Thromboembolic Disorder - Obstruction of a Blood Vessel by a Blood Clot is a contraindication of Prempro.

Thrombophlebitis - Blood Clot in Vein is a contraindication of Prempro.

Relative Contraindications 

Alcoholism - Habit of Drinking Too Much Alcohol is a contraindication of Prempro.

Anorexia Nervosa is a contraindication of Prempro.

Coronary Artery Disease - Disease of the Arteries of the Heart is a contraindication of Prempro.

Dementia - Disorder of Mental Processes due to a Brain Disease is a contraindication of Prempro.

Endometrial Carcinoma - Cancer in the Lining of the Uterus is a contraindication of Prempro.

Familial History of Breast Carcinoma - Family History of Breast Cancer is a contraindication of Prempro.

Gallbladder Disease - Disease of the Gallbladder is a contraindication of Prempro.

Hypercalcemia associated with Metastatic Breast Carcinoma - High Amount of Blood Calcium from Spread of Breast Cancer is a contraindication of Prempro.

Hypercholesterolemia - High Cholesterol is a contraindication of Prempro.

Hyperlipoproteinemia is a contraindication of Prempro.

Hypertension - High Blood Pressure is a contraindication of Prempro.

Increased Cardiovascular Event Risk is a contraindication of Prempro.

Obesity - Overweight is a contraindication of Prempro.

Osteopenia - Decreased Calcification or Density of Bone is a contraindication of Prempro.

Osteoporosis is a contraindication of Prempro.

Ovarian Carcinoma - Cancer of the Ovary is a contraindication of Prempro.

Retinal Thrombosis - A Blood Clot within the Blood Vessels of the Eye is a contraindication of Prempro.

Thrombophlebitis - Blood Clot in Vein is a contraindication of Prempro.

Tobacco Smoker - Tobacco Smoking is a contraindication of Prempro.

Vision Loss - Poor Vision is a contraindication of Prempro.

Contraindication Warnings 

Body Fluid Retention - Water Retention is a contraindication of Prempro.

Breast Fibroadenosis - Presence of Nodules in the Breast is a contraindication of Prempro.

Bronchial Asthma - Asthma is a contraindication of Prempro.

Chloasma - Yellow-Brown Patches on Skin is a contraindication of Prempro.

Chorea - Irregular Involuntary Spasms of Limbs or Facial Muscles is a contraindication of Prempro.

Depression is a contraindication of Prempro.

Diabetes Mellitus - Diabetes is a contraindication of Prempro.

Endometriosis is a contraindication of Prempro.

Epilepsy - Epileptic Seizure is a contraindication of Prempro.

Familial History of Breast Carcinoma - Family History of Breast Cancer is a contraindication of Prempro.

Hepatic Porphyria is a contraindication of Prempro.

Hyperlipidemia - High Amount of Fats in the Blood is a contraindication of Prempro.

Hypertension - High Blood Pressure is a contraindication of Prempro.

Hypertriglyceridemia - High Amount of Triglyceride in the Blood is a contraindication of Prempro.

Hypocalcemia - Low Amount of Calcium in the Blood is a contraindication of Prempro.

Hypothyroidism - Underactive Thyroid is a contraindication of Prempro.

Lumps in Breasts - Lump in the Breast is a contraindication of Prempro.

Mammography Abnormal is a contraindication of Prempro.

Migraine - Migraine Headache is a contraindication of Prempro.

Renal Disease - Kidney Disease is a contraindication of Prempro.

Systemic Lupus Erythematosus is a contraindication of Prempro.

Uterine Fibroids is a contraindication of Prempro.

Weight Gain is a contraindication of Prempro.

Prempro has 10 related brands and strengths:
 
Conjug. Estrogen-Medroxyprogesterone 0.3 Mg-1.5 Mg Tab

Conjug. Estrogen-Medroxyprogesterone 0.45 Mg-1.5 Mg Tab

Conjug. Estrogen-Medroxyprogesterone 0.625 Mg(14)/0.625 Mg-5mg(14) Tab

Conjug. Estrogen-Medroxyprogesterone 0.625 Mg-2.5 Mg Tab

Conjug. Estrogen-Medroxyprogesterone 0.625 Mg-5 Mg Tab

Premphase 0.625 Mg(14)/0.625 Mg-5mg(14) Tab

Prempro 0.3 Mg-1.5 Mg Tab

Prempro 0.45 Mg-1.5 Mg Tab

Prempro 0.625 Mg-2.5 Mg Tab

Prempro 0.625 Mg-5 Mg Tab

Prempro - Symptoms of overdose may include
severe nausea/vomiting, unusual vaginal bleeding in females.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

IMPORTANT NOTICE: The drug information contained in this application is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not exhaustive and is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express terms of use. By continuing to view the drug information on this site, you agree to abide by such terms of use.
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