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Drug Interactions and Side Effects of Spironolactone

Spironolactone has 33 Side Effects total
15 are Life Threatening
2 Occur Most Frequently

Uses of Spironolactone
 
USES:
Spironolactone is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (e.g., congestive heart failure) by removing excess fluid and improving symptoms such as breathing problems.

This medication is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone).

Spironolactone is known as a "water pill" (potassium-sparing diuretic).


Spironolactone has 15 Life Threatening (Critical) Side Effects
 
Critical Seriousness - Allergic Reaction causing Inflammation of Blood Vessels - Hypersensitivity Angiitis is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Bleeding of the Stomach or Intestines - Gastrointestinal Hemorrhage is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Deficiency of Granulocytes a Type of White Blood Cell - Agranulocytosis is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Discolored Spots and Small Elevations of the Skin - Maculopapular Rash is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - High Amount of Potassium in the Blood - Hyperkalemia is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Hives - Urticaria is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Inflammation of Skin caused by an Allergy - Allergic Dermatitis is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Inflammation of the Liver with Stoppage of Bile Flow - Cholestatic Hepatitis is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Itching - Pruritus of Skin is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Kidney Disease - Renal Disease is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Life Threatening Allergic Reaction - Anaphylaxis is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Rash - Skin Rash is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Reaction due to an Allergy - Allergic Reactions is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Stomach Ulcer - Gastric Ulcer is a Life Threatening Side Effect of Spironolactone
Critical Seriousness - Trouble Breathing - Dyspnea is a Life Threatening Side Effect of Spironolactone

Spironolactone has 2 Most Frequently Occurring Side Effects
 
High Amount of Potassium in the Blood - Hyperkalemia is a Frequently Occurring Side Effect of Spironolactone
Irritation of the Stomach or Intestines - Gastrointestinal Irritation is a Frequently Occurring Side Effect of Spironolactone

Spironolactone Drug-Drug Interactions
 
Spironolactone has interactions of severe seriousness with 8 drug(s):
Spironolactone has 2 severe interactions with Cyclosporine. Click here to see them
Spironolactone has 1 severe interactions with Cyclosporine Modified. Click here to see them
Spironolactone has 1 severe interactions with Gengraf. Click here to see them
Spironolactone has 1 severe interactions with Neoral. Click here to see them
Spironolactone has 1 severe interactions with Prograf. Click here to see them
Spironolactone has 1 severe interactions with Sandimmune. Click here to see them
Spironolactone has 1 severe interactions with Sangcya. Click here to see them
Spironolactone has 2 severe interactions with Tacrolimus. Click here to see them

Spironolactone has interactions of serious seriousness with 299 drug(s).

Spironolactone has interactions of moderate seriousness with 108 drug(s).

Spironolactone has interactions of unknown seriousness with 0 drug(s).

Spironolactone has 9 Condition Contraindications
 
If you have any of these Conditions then you should carefully evaluate the risks of taking Spironolactone.

Spironolactone Oral Contraindications
(grouped by decreasing seriouosness level)

Absolute Contraindications 

Acute Renal Disease - Acute Kidney Disease is a contraindication of Spironolactone.

Anuria - Absence of Urine Formation is a contraindication of Spironolactone.

Hyperkalemia - High Amount of Potassium in the Blood is a contraindication of Spironolactone.

Severe Renal Disease - Serious Kidney Problems is a contraindication of Spironolactone.

Relative Contraindications 

Dehydration - Extreme Loss of Body Water is a contraindication of Spironolactone.

Hyperchloremic Acidosis - Excess Body Acid and Chloride is a contraindication of Spironolactone.

Hyponatremia - Low Amount of Sodium in the Blood is a contraindication of Spironolactone.

Hypovolemia - Decreased Blood Volume is a contraindication of Spironolactone.

Contraindication Warnings 

Renal Disease - Kidney Disease is a contraindication of Spironolactone.

Spironolactone has 6 related brands and strengths:
 
Aldactone 100 Mg Tab

Aldactone 25 Mg Tab

Aldactone 50 Mg Tab

Spironolactone 100 Mg Tab

Spironolactone 25 Mg Tab

Spironolactone 50 Mg Tab

Spironolactone - Symptoms of overdose may include
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

Contact poison control
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

IMPORTANT NOTICE: The drug information contained in this application is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not exhaustive and is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express terms of use. By continuing to view the drug information on this site, you agree to abide by such terms of use.
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